Evidence map›Paper›PMID 27694951›Full record

SynthesisScientific reports2016

Prognostic Significance of Neutrophil to Lymphocyte Ratio in Oncologic Outcomes of Cholangiocarcinoma: A Meta-analysis.

De-Wen Tan, Yan Fu, Qi Su, Ming-Jun Guan, Po Kong, Sheng-Qiang Wang, He-Ling Wang

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 6 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 6 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

De-Wen TanDepartment of General Surgery, Shengjing Hospital Affiliated with China Medical University, Shenyang, Liaoning 110004, China.
Yan FuDepartment of Head and Neck Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Qi SuDepartment of General Surgery, Shengjing Hospital Affiliated with China Medical University, Shenyang, Liaoning 110004, China.
Ming-Jun GuanDepartment of General Surgery, Shengjing Hospital Affiliated with China Medical University, Shenyang, Liaoning 110004, China.
Po KongDepartment of General Surgery, Shengjing Hospital Affiliated with China Medical University, Shenyang, Liaoning 110004, China.
Sheng-Qiang WangDepartment of General Surgery, Shengjing Hospital Affiliated with China Medical University, Shenyang, Liaoning 110004, China.
He-Ling WangDepartment of General Surgery, Shengjing Hospital Affiliated with China Medical University, Shenyang, Liaoning 110004, China.
China Medical University · CNSun Yat-sen University Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence indicates that the neutrophil to lymphocyte ratio (NLR) is a useful biomarker of long-term outcomes in patients with cholangiocarcinoma. However, the prognostic role of NLR in patients with cholangiocarcinoma remains unclear. Thus, the current meta-analysis was undertaken to clarify the correlation between NLR and overall survival (OS) in cholangiocarcinoma, and a comprehensive literature research was conducted to understand the association of NLR and prognosis of cholangiocarcinoma. The hazard ratio (HR) with 95% confidence interval (CI) was used to assess OS. The synthesized HR of 1.449 (95% CI: 1.296-1.619, P < 0.001) indicated that a high NLR had an unfavourable effect on OS. Overall, this meta-analysis suggested that elevated preoperative NLR is associated with poorer rates of survival in cholangiocarcinoma patients.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaLymphocytesNeutrophilsBiomarkers, TumorDisease-Free SurvivalFemaleHumansLymphocyte CountMaleSurvival RateBiomarkers, Tumor

Identifiers

PMID27694951
PMCPMC5046177
OpenAlexW2529550854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.