Evidence map›Paper›PMID 27694947›Full record

ArticleNature communications2016

Organization of olfactory centres in the malaria mosquito Anopheles gambiae.

Olena Riabinina, Darya Task, Elizabeth Marr, Chun-Chieh Lin, Robert Alford, David A O'Brochta, Christopher J Potter

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 186 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. The sensory biology of mosquito gustation.Current opinion in neurobiology · 2026
    Review
  7. A Molecular and Cellular Mechanism for Bitter Taste in the mosquitobioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. The GABAiScience · 2025
    Article
  18. Article
  19. Review
  20. Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Olena RiabininaThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, 434 Rangos Building, Baltimore, Maryland 21205, USA.
Darya TaskThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, 434 Rangos Building, Baltimore, Maryland 21205, USA.
Elizabeth MarrThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, 434 Rangos Building, Baltimore, Maryland 21205, USA.
Chun-Chieh LinThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, 434 Rangos Building, Baltimore, Maryland 21205, USA.
Robert AlfordUniversity of Maryland College Park, 9600 Gudelsky Drive, Rockville, Maryland 20850, USA.
David A O'BrochtaUniversity of Maryland College Park, 9600 Gudelsky Drive, Rockville, Maryland 20850, USA.
Christopher J PotterThe Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, 434 Rangos Building, Baltimore, Maryland 21205, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USUniversity of Maryland, College Park · US

Funding

The Histology CoreP30DC005211 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI YOUNG, ERIC DANIEL · 2002 to 2016
$9.1M
Neural circuits mediating food, pherome, and repulsive odor behaviorsR01DC013079 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI POTTER, CHRISTOPHER JOHN · 2013 to 2017
$2.0M
Genetic Analysis of Anopheles mosquitoesR01AI099060 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI O'BROCHTA, DAVID A · 2013 to 2016
$1.3M
NIAID NIH HHS R01 AI099060NIDCD NIH HHS P30 DC005211NIDCD NIH HHS R01 DC013079
6 · The paper itself

Abstract

Mosquitoes are vectors for multiple infectious human diseases and use a variety of sensory cues (olfactory, temperature, humidity and visual) to locate a human host. A comprehensive understanding of the circuitry underlying sensory signalling in the mosquito brain is lacking. Here we used the Q-system of binary gene expression to develop transgenic lines of Anopheles gambiae in which olfactory receptor neurons expressing the odorant receptor co-receptor (Orco) gene are labelled with GFP. These neurons project from the antennae and maxillary palps to the antennal lobe (AL) and from the labella on the proboscis to the suboesophageal zone (SEZ), suggesting integration of olfactory and gustatory signals occurs in this brain region. We present detailed anatomical maps of olfactory innervations in the AL and the SEZ, identifying glomeruli that may respond to human body odours or carbon dioxide. Our results pave the way for anatomical and functional neurogenetic studies of sensory processing in mosquitoes.

Indexed as

SmellAnimalsAnimals, Genetically ModifiedAnophelesBrainFemaleGene Expression ProfilingGene Expression RegulationGreen Fluorescent ProteinsMalariaMaleMosquito VectorsNeuronsOlfactory PathwaysOlfactory Receptor NeuronsReceptors, OdorantGreen Fluorescent ProteinsReceptors, Odorant

Identifiers

PMID27694947
PMCPMC5063964
OpenAlexW2529074512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.