Evidence map›Paper›PMID 27694934›Full record

ArticleNature medicine2016

Translocation and dissemination of commensal bacteria in post-stroke infection.

Dragana Stanley, Linda J Mason, Kate E Mackin, Yogitha N Srikhanta, Dena Lyras, Monica D Prakash, Kulmira Nurgali, Andres Venegas, Michael D Hill, Robert J Moore and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 268 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
268citing papers in PubMed, 6 pooled it
44.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

268 citing papers in PubMed, 6 syntheses or guidelines pooled it, 447 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

208 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Dragana StanleySchool of Medical and Applied Sciences, Central Queensland University, Rockhampton, Queensland, Australia.
Linda J MasonDepartment of Biochemistry, Monash University, Clayton, Victoria, Australia.
Kate E MackinInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Yogitha N SrikhantaInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Dena LyrasInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Monica D PrakashCentre for Chronic Diseases, College of Health and Biomedicine, Victoria University, St. Albans, Victoria, Australia.
Kulmira NurgaliCentre for Chronic Diseases, College of Health and Biomedicine, Victoria University, St. Albans, Victoria, Australia.
Andres VenegasStroke Unit, Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Michael D HillStroke Unit, Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Robert J MooreInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-0776-5861
Connie H Y WongCentre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
Australian Regenerative Medicine Institute · AUMonash University · AUUniversity of Calgary · CAVictoria University · AUCentral Queensland University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial infection is highly prevalent in patients who have had a stroke. Despite the potential contribution of micro-aspiration in post-stroke pneumonia, we found that the majority of the microorganisms detected in the patients who developed infections after having a stroke were common commensal bacteria that normally reside in the intestinal tracts. In a mouse model of ischemic stroke, post-stroke infection was only observed in mice that were born and raised in specific-pathogen-free facilities; this was not seen in mice that were born and raised in germ-free facilities. Using high-throughput 16S rRNA gene amplicon sequencing and bioinformatics analyses, we provide evidence demonstrating that the source of the bacteria forming the microbial community in the lungs of post-stroke mice was indeed the host small intestine. Additionally, stroke-induced gut barrier permeability and dysfunction preceded the dissemination of orally inoculated bacteria to peripheral tissues. This study identifies a novel pathway in which stroke promotes the translocation and dissemination of selective strains of bacteria that originated from the host gut microbiota.

Indexed as

Adrenergic beta-AntagonistsAgedAged, 80 and overAnimalsBacteremiaBacterial InfectionsBacterial TranslocationBlood CultureComputational BiologyDisease Models, AnimalEnterococcus faecalisFemaleGastrointestinal MicrobiomeGoblet CellsGram-Positive Bacterial InfectionsHigh-Throughput Nucleotide SequencingAdrenergic beta-AntagonistsReceptors, Adrenergic, betaRNA, Ribosomal, 16STjp1 protein, mouseZonula Occludens-1 Protein

Identifiers

PMID27694934
OpenAlexW2527885929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.