ArticleNature communications2016
Noise reduction facilitated by dosage compensation in gene networks.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Current Progress and Future Outlook for Synthetic Gene Circuits in Cardiovascular Therapy.Biomolecules · 2026Review
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- Computational Systems Biology Approaches to Cellular Aging - Integrating Network Maps and Dynamical Models.Quantitative biology (Beijing, China) · 2025Article
- Associative conditioning in gene regulatory network models increases integrative causal emergence.Communications biology · 2025Article
- Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine.iScience · 2025Article
- Phenotypic heterogeneity follows a growth-viability tradeoff in response to amino acid identity.Nature communications · 2024Article
- The duplication of genomes and genetic networks and its potential for evolutionary adaptation and survival during environmental turmoil.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Toward predictive engineering of gene circuits.Trends in biotechnology · 2023Review
- Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes.iScience · 2022Article
- Phenotypic plasticity as a facilitator of microbial evolution.Environmental epigenetics · 2022Review
- Modeling aging and its impact on cellular function and organismal behavior.Experimental gerontology · 2021Review
- A synthetic circuit for buffering gene dosage variation between individual mammalian cells.Nature communications · 2021Article
- Article
- Synchronization of stochastic expressions drives the clustering of functionally related genes.Science advances · 2019Article
- Insights into Bidirectional Gene Expression Control Using the Canonical GAL1/GAL10 Promoter.Cell reports · 2018Article
- The Systems Biology of Single-Cell Aging.iScience · 2018Review
- Multi-component gene network design as a survival strategy in diverse environments.BMC systems biology · 2018Article
- Coupling of DNA Replication and Negative Feedback Controls Gene Expression for Cell-Fate Decisions.iScience · 2018Article
- Noise reduction as an emergent property of single-cell aging.Nature communications · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic noise together with genome duplication and volume changes during cell cycle are significant contributors to cell-to-cell heterogeneity. How can cells buffer the effects of these unavoidable epigenetic and genetic variations on phenotypes that are sensitive to such variations? Here we show that a simple network motif that is essential for network-dosage compensation can reduce the effects of extrinsic noise on the network output. Using natural and synthetic gene networks with and without the network motif, we measure gene network activity in single yeast cells and find that the activity of the compensated network is significantly lower in noise compared with the non-compensated network. A mathematical analysis provides intuitive insights into these results and a novel stochastic model tracking cell-volume and cell-cycle predicts the experimental results. Our work implies that noise is a selectable trait tunable by evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.