ArticleNature communications2016
Excess of mutational jackpot events in expanding populations revealed by spatial Luria-Delbrück experiments.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
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- Minding the gap: collective determinants of multiscale structure across interacting bacterial colonies.bioRxiv : the preprint server for biology · 2026Article
- Selective sweep probabilities in spatially expanding populations.Nature communications · 2026Article
- Spatial structure: shaping the ecology and evolution of microbial communities.FEMS microbiology reviews · 2026Review
- Efficient mathematical methodology to determine multistep mutant burden in spatially growing cell populations.PNAS nexus · 2025Article
- Extrachromosomal DNA: shaping the evolutionary dynamics of cancer.Trends in cancer · 2025Review
- Quantitative and sensitive sequencing of somatic mutations induced by a maize transposon.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Antimutator and Mutational Spectrum Effects Can Combine to Reduce Evolutionary Potential in Escherichia coli ΔnudJ.Molecular biology and evolution · 2025Article
- Geometry-induced competitive release in a meta-population model of range expansions in disordered environments.Journal of the Royal Society, Interface · 2025Article
- Factors that influence the caste ratio in a bacterial division of labour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Range expansions across landscapes with quenched noise.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Vancomycin-resistant Staphylococcus aureus (VRSA) can overcome the cost of antibiotic resistance and may threaten vancomycin's clinical durability.PLoS pathogens · 2024Article
- Tuning interdomain conjugation to enablemSystems · 2024Article
- Substrate geometry affects population dynamics in a bacterial biofilm.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Adaptive laboratory evolution of Clostridium autoethanogenum to metabolize COMicrobial biotechnology · 2024Article
- Restoring the Fluctuation-Dissipation Theorem in Kardar-Parisi-Zhang Universality Class through a New Emergent Fractal Dimension.Entropy (Basel, Switzerland) · 2024Article
- Genetic mixing and demixing on expanding spherical frontiers.ISME communications · 2024Article
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3 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
The genetic diversity of growing cellular populations, such as biofilms, solid tumours or developing embryos, is thought to be dominated by rare, exceptionally large mutant clones. Yet, the emergence of these mutational jackpot events is only understood in well-mixed populations, where they stem from mutations that arise during the first few cell divisions. To study jackpot events in spatially structured populations, we track mutant clones in microbial populations using fluorescence microscopy and population sequencing. High-frequency mutations are found to be massively enriched in microbial colonies compared with well-shaken liquid cultures, as a result of late-occurring mutations surfing at the edge of range expansions. Thus, jackpot events can be generated not only when mutations arise early but also when they occur at favourable locations, which exacerbates their role in adaptation and disease. In particular, because spatial competition with the wild type keeps most mutant clones in a quiescent state, strong selection pressures that kill the wild type promote drug resistance.
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