ArticleMedicina oral, patologia oral y cirugia bucal2016
Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements.
Article in Medicina oral, patologia oral y cirugia bucal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Lubricin Levels in Temporomandibular Joint Disorders: A Scoping Review.International journal of molecular sciences · 2026Article
- Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future.The journal of pain · 2025Review
- Intra-Articular Administration of Recombinant Human Proteoglycan 4 (rhPRG4) as a Potential Therapy for Temporomandibular Joint Osteoarthritis: A Preclinical Histopathological Study.International journal of molecular sciences · 2025Article
- Pregnancy related factors and temporomandibular disorders evaluated through the diagnostic criteria for temporomandibular disorders (DC/TMD) axis II: a cross sectional study.BMC oral health · 2024Article
- Immunohistochemical Markers of Temporomandibular Disorders: A Review of the Literature.Journal of clinical medicine · 2023Review
- MMPs in tissues retrieved during surgery from patients with TMJ disorders relate to pain more than to radiological damage score.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Class II Skeletal Malocclusion and Prevalence of Temporomandibular Disorders. An Epidemiological Pilot Study on Growing Subjects.Journal of functional morphology and kinesiology · 2021Article
- Craniomandibular Disorders in Pregnant Women: An Epidemiological Survey.Journal of functional morphology and kinesiology · 2020Article
- Temporomandibular joint damage in K/BxN arthritic mice.International journal of oral science · 2020Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs). MATERIAL AND
methodsA total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system.
resultsThe mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score.
conclusionsThe results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed.
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