Evidence map›Paper›PMID 27694627›Full record

ArticleGenetics2016

Genetics of Skeletal Evolution in Unusually Large Mice from Gough Island.

Michelle D Parmenter, Melissa M Gray, Caley A Hogan, Irene N Ford, Karl W Broman, Christopher J Vinyard, Bret A Payseur

Abstract read
In one paragraph

Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Phenotypic and developmental dissection of an instance of the island rule.Evolution; international journal of organic evolution · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michelle D ParmenterLaboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706.
Melissa M GrayLaboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706.
Caley A HoganLaboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706.
Irene N FordLaboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706.
Karl W BromanDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin 53706.
Christopher J VinyardDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, Ohio 44272.
Bret A PayseurLaboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706 bret.payseur@wisc.edu.

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
The Genetics and Evolution of Extreme Body Size in Mice from Gough IslandR01GM100426 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PAYSEUR, BRET A · 2012 to 2020
$3.6M
Genetics and evolution of extreme body size in an island population of house miceF32GM090685 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GRAY, MELISSA MARIE · 2010 to 2012
$146k
NIGMS NIH HHS F32 GM090685NIGMS NIH HHS R01 GM100426NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

Organisms on islands often undergo rapid morphological evolution, providing a platform for understanding mechanisms of phenotypic change. Many examples of evolution on islands involve the vertebrate skeleton. Although the genetic basis of skeletal variation has been studied in laboratory strains, especially in the house mouse Mus musculus domesticus, the genetic determinants of skeletal evolution in natural populations remain poorly understood. We used house mice living on the remote Gough Island-the largest wild house mice on record-to understand the genetics of rapid skeletal evolution in nature. Compared to a mainland reference strain from the same subspecies (WSB/EiJ), the skeleton of Gough Island mice is considerably larger, with notable expansions of the pelvis and limbs. The Gough Island mouse skeleton also displays changes in shape, including elongations of the skull and the proximal vs. distal elements in the limbs. Quantitative trait locus (QTL) mapping in a large F

Indexed as

Evolution, MolecularQuantitative Trait LociAnimalsBody SizeBone and BonesFemaleGenetic PleiotropyIslandsMaleMicebody sizecomplex traitisland syndromephenotypic extremepleiotropyskeletal evolution

Identifiers

PMID27694627
PMCPMC5161285

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.