SynthesisInternational journal of immunopathology and pharmacology2016
Critical evaluation of challenges and future use of animals in experimentation for biomedical research.
Synthesis in International journal of immunopathology and pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human-relevant translation.Animal models and experimental medicine · 2026Review
- Hematological and Biochemical Outcomes of Leishmania Infantum Infection in the South American Coati (Nasua nasua) in an Endemic Area of Visceral Leishmaniasis in Central Western Brazil.Acta parasitologica · 2026Article
- Interrelationship Between Physical Exercise and Apical Periodontitis in Trained Rats.International journal of dentistry · 2026Article
- Toward a roadmap for addressing today's health dilemma-The 101-statement consensus report.Frontiers in nutrition · 2025Article
- Challenges and opportunities of translating animal research into human trials in Ethiopia.BMC medical research methodology · 2024Article
- The Impact of Nanomedicine on Soft Tissue Sarcoma Treated by Radiotherapy and/or Hyperthermia: A Review.Cancers · 2024Review
- Exercise for Mental Well-Being: Exploring Neurobiological Advances and Intervention Effects in Depression.Life (Basel, Switzerland) · 2023Review
- Functional Surface Coatings on Orthodontic Appliances: Reviews of Friction Reduction, Antibacterial Properties, and Corrosion Resistance.International journal of molecular sciences · 2023Review
- DRPreter: Interpretable Anticancer Drug Response Prediction Using Knowledge-Guided Graph Neural Networks and Transformer.International journal of molecular sciences · 2022Article
- In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed.Angiogenesis · 2022Article
- How Does Botulinum Toxin Inhibit Itch?Toxins · 2022Review
- Ethical considerations regarding animal experimentation.Journal of preventive medicine and hygiene · 2022Review
- Experimental Applications and Factors Involved in Validating Thermal Windows Using Infrared Thermography to Assess the Health and Thermostability of Laboratory Animals.Animals : an open access journal from MDPI · 2021Review
- Species variations in tenocytes' response to inflammation require careful selection of animal models for tendon research.Scientific reports · 2021Article
- Article
- Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives.International journal of molecular sciences · 2020Review
- Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals.BMJ open science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal experiments that are conducted worldwide contribute to significant findings and breakthroughs in the understanding of the underlying mechanisms of various diseases, bringing up appropriate clinical interventions. However, their predictive value is often low, leading to translational failure. Problems like translational failure of animal studies and poorly designed animal experiments lead to loss of animal lives and less translatable data which affect research outcomes ethically and economically. Due to increasing complexities in animal usage with changes in public perception and stringent guidelines, it is becoming difficult to use animals for conducting studies. This review deals with challenges like poor experimental design and ethical concerns and discusses key concepts like sample size, statistics in experimental design, humane endpoints, economic assessment, species difference, housing conditions, and systematic reviews and meta-analyses that are often neglected. If practiced, these strategies can refine the procedures effectively and help translate the outcomes efficiently.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.