ArticleInternational journal of epidemiology2017
Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population.
Article in International journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-analysis.JAMA psychiatry · 2020Pooled it
- The effectiveness and cost-effectiveness of the Incredible Years® Teacher Classroom Management programme in primary school children: results of the STARS cluster randomised controlled trial.Psychological medicine · 2019Trial
- Investigating the associations between neurodevelopmental and psychiatric genetic liability and adverse social and functional outcomes across childhood, adolescence and young-adulthood.Molecular psychiatry · 2026Article
- Polygenic risk score for neurodevelopmental disorders and cognitive impairment at long-term follow-up of first-episode psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Associations of ADHD genetic risk with objective and subjective economic wellbeing: evidence from Finnish population-based cohorts.Social psychiatry and psychiatric epidemiology · 2026Article
- Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Childhood trajectories of internalising and externalising problems associated with a polygenic risk score for neuroticism in a UK birth cohort study.JCPP advances · 2023Article
- Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2023Article
- How interactions between ADHD and schools affect educational achievement: a family-based genetically sensitive study.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study.American journal of human genetics · 2022Article
- Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children.Psychological medicine · 2022Article
- The role of ADHD genetic risk in mid-to-late life somatic health conditions.Translational psychiatry · 2022Article
- Is genetic liability to ADHD and ASD causally linked to educational attainment?International journal of epidemiology · 2022Article
- Resource profile and user guide of the Polygenic Index Repository.Nature human behaviour · 2021Article
- Article
- Gene-environment dependencies lead to collider bias in models with polygenic scores.Scientific reports · 2021Article
- Disentangling nature from nurture in examining the interplay between parent-child relationships, ADHD, and early academic attainment.Psychological medicine · 2021Article
- Multi-omics analyses of cognitive traits and psychiatric disorders highlights brain-dependent mechanisms.Human molecular genetics · 2021Article
- Common health conditions in childhood and adolescence, school absence, and educational attainment: Mendelian randomization study.NPJ science of learning · 2021Article
- Article
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8 authors.
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Abstract
Background: Children with a diagnosis of attention-deficit hyperactivity disorder ADHD) have lower cognitive ability and are at risk of adverse educational outcomes; ADHD genetic risks have been found to predict childhood cognitive ability and other neurodevelopmental traits in the general population; thus genetic risks might plausibly also contribute to cognitive ability later in development and to educational underachievement. Methods: We generated ADHD polygenic risk scores in the Avon Longitudinal Study of Parents and Children participants (maximum N : 6928 children and 7280 mothers) based on the results of a discovery clinical sample, a genome-wide association study of 727 cases with ADHD diagnosis and 5081 controls. We tested if ADHD polygenic risk scores were associated with educational outcomes and IQ in adolescents and their mothers. Results: High ADHD polygenic scores in adolescents were associated with worse educational outcomes at Key Stage 3 [national tests conducted at age 13-14 years; β = -1.4 (-2.0 to -0.8), P = 2.3 × 10 -6 ), at General Certificate of Secondary Education exams at age 15-16 years (β = -4.0 (-6.1 to -1.9), P = 1.8 × 10 -4 ], reduced odds of sitting Key Stage 5 examinations at age 16-18 years [odds ratio (OR) = 0.90 (0.88 to 0.97), P = 0.001] and lower IQ scores at age 15.5 [β = -0.8 (-1.2 to -0.4), P = 2.4 × 10 -4 ]. Moreover, maternal ADHD polygenic scores were associated with lower maternal educational achievement [β = -0.09 (-0.10 to -0.06), P = 0.005] and lower maternal IQ [β = -0.6 (-1.2 to -0.1), P = 0.03]. Conclusions: ADHD diagnosis risk alleles impact on functional outcomes in two generations (mother and child) and likely have intergenerational environmental effects.
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