Evidence map›Paper›PMID 27694480›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017

Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.

Philippe Selhorst, Lindi Masson, Sherazaan D Ismail, Natasha Samsunder, Nigel Garrett, Leila E Mansoor, Quarraisha Abdool Karim, Salim S Abdool Karim, Jo-Ann S Passmore, Carolyn Williamson

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Semen: A modulator of female genital tract inflammation and a vector for HIV-1 transmission.American journal of reproductive immunology (New York, N.Y. : 1989) · 2021
    Review
  8. Article
  9. Betamethasone induces potent immunosuppression and reduces HIV infection in a PBMC in vitro model.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021
    Article
  10. Review
  11. Article
  12. TheFuture virology · 2020
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Philippe SelhorstInstitute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.
Lindi MassonInstitute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.
Sherazaan D IsmailInstitute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.
Natasha SamsunderCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Nigel GarrettCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Leila E MansoorCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Quarraisha Abdool KarimCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Salim S Abdool KarimCentre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban.
Jo-Ann S PassmoreInstitute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.
Carolyn WilliamsonInstitute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Services.

Funding

The Viral Set Point in HIV-1 Subtype C InfectionU19AI051794 · NIAID · UNIVERSITY OF KWAZULU-NATAL · PI ABDOOL KARIM, SALIM S · 2002 to 2007
$22.5M
NIAID NIH HHS U19 AI051794Wellcome Trust
6 · The paper itself

Abstract

We evaluated whether genital inflammation affects the selection of the transmitted virus. Among South African women, we found that preinfection genital inflammation facilitates transmission of less infectious human immunodeficiency virus, but highly infectious viruses are able to establish infection regardless of inflammation status. This suggests that viral phenotype can influence transmission risk.

Indexed as

BiomarkersCytokinesFemaleHIV-1HIV InfectionsHumansPhylogenyUterine CervicitisVaginitisViral LoadBiomarkersCytokinescytokinefemale genital tractHIV acquisitioninflammationviral infectivity

Identifiers

PMID27694480
PMCPMC5159604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.