Evidence map›Paper›PMID 27694475›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2016

Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections.

Ranu Surolia, Suman Karki, Zheng Wang, Tejaswini Kulkarni, Fu Jun Li, Shikhar Vohra, Hitesh Batra, Jerry A Nick, Steven R Duncan, Victor J Thannickal and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. C3HeB/FeJ mice with chronicMycobacteria (London, England) · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Pathophysiological Role of Vimentin Intermediate Filaments in Lung Diseases.Frontiers in cell and developmental biology · 2022
    Review
  8. The Role of NRF2 in Mycobacterial Infection.Antioxidants (Basel, Switzerland) · 2021
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections.American journal of respiratory cell and molecular biology · 2020
    Review
  15. Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace.American journal of physiology. Lung cellular and molecular physiology · 2018
    Review
  16. Article
  17. Role of apoptosis and autophagy in tuberculosis.American journal of physiology. Lung cellular and molecular physiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Ranu SuroliaDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.ORCID 0000-0001-5389-3584
Suman KarkiDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
Zheng WangDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
Tejaswini KulkarniDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
Fu Jun LiDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
Shikhar VohraDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
Hitesh BatraDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
Jerry A NickDepartment of Medicine, National Jewish Health, University of Colorado, Denver, Colorado.
Steven R DuncanDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
Victor J ThannickalDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
Adrie J C SteynDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama.
Anupam AgarwalDepartment of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama.
Veena B AntonyDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, Alabama; vantony@uabmc.edu.
University of Alabama at Birmingham · USNational Jewish Health · US

Funding

Human Heme Oxygenase-1 Gene Regulation in Renal InjuryR01DK059600 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ANUPAM, GEORGE, JAMES F · 2002 to 2019
$4.5M
NIDDK NIH HHS R01 DK059600
6 · The paper itself

Abstract

Pulmonary infections with nontuberculous mycobacteria (P-NTM), such as by Mycobacterium avium complex (M. avium), are increasingly found in the elderly, but the underlying mechanisms are unclear. Recent studies suggest that adaptive immunity is necessary, but not sufficient, for host defense against mycobacteria. Heme oxygenase-1 (HO-1) has been recognized as a critical modulator of granuloma formation and programmed cell death in mycobacterial infections. Old mice (18-21 mo) infected with M. avium had attenuated HO-1 response with diffuse inflammation, high burden of mycobacteria, poor granuloma formation, and decreased survival (45%), while young mice (4-6 mo) showed tight, well-defined granuloma, increased HO-1 expression, and increased survival (95%). To further test the role of HO-1 in increased susceptibility to P-NTM infections in the elderly, we used old and young HO-1

Indexed as

AgedAgingAnimalsCell DeathDisease SusceptibilityGene Expression Regulation, EnzymologicGranulomaHeme Oxygenase-1HumansLeukocytes, MononuclearMice, Inbred C57BLMycobacterium aviumMycobacterium Infections, NontuberculousProto-Oncogene Proteins c-bcl-2Respiratory Tract InfectionsSuppressor of Cytokine Signaling 3 ProteinHeme Oxygenase-1Proto-Oncogene Proteins c-bcl-2Socs3 protein, mouseSuppressor of Cytokine Signaling 3 Proteinagingcell deathheme oxygenase 1nontuberculosis mycobacteriumSOCS3

Identifiers

PMID27694475
PMCPMC5504405
OpenAlexW2527053691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.