ArticleBlood2016
Polyphosphate colocalizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity.
Article in Blood, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Surface-dependent reactions in blood coagulation and fibrinolysis: beyond procoagulant platelets.Biophysical reviews · 2025Review
- Plasma Gel Made of Platelet-Poor Plasma: In Vitro Verification as a Carrier of Polyphosphate.Biomedicines · 2023Article
- Intersection of Coagulation and Fibrinolysis by the Glycosylphosphatidylinositol (GPI)-Anchored Serine Protease Testisin.International journal of molecular sciences · 2023Article
- All tangled up: interactions of the fibrinolytic and innate immune systems.Frontiers in medicine · 2023Review
- Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Review
- Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi.Frontiers in cardiovascular medicine · 2022Review
- uPA-mediated plasminogen activation is enhanced by polyphosphate.Haematologica · 2021Article
- Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.Blood · 2021Article
- Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 Cells.Marine drugs · 2020Article
- A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation.The Journal of biological chemistry · 2020Article
- Platelet Membrane Receptor Proteolysis: Implications for Platelet Function.Frontiers in cardiovascular medicine · 2020Review
- From underlying chemistry to therapeutic potential: open questions in the new field of lysine polyphosphorylation.Current genetics · 2019Review
- Plasminflammation-An Emerging Pathway to Bradykinin Production.Frontiers in immunology · 2019Review
- Immunohaemostasis: a new view on haemostasis during sepsis.Annals of intensive care · 2017Review
- Live-cell Imaging of Platelet Degranulation and Secretion Under Flow.Journal of visualized experiments : JoVE · 2017Article
- The Procoagulant Activity of Apoptotic Cells Is Mediated by Interaction with Factor XII.Frontiers in immunology · 2017Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Activated factor XII (FXIIa) has plasminogen activator capacity but its relative contribution to fibrinolysis is considered marginal compared with urokinase and tissue plasminogen activator. Polyphosphate (polyP) is released from activated platelets and mediates FXII activation. Here, we investigate the contribution of polyP to the plasminogen activator function of αFXIIa. We show that both polyP
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.