Evidence map›Paper›PMID 27694179›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2016

Prostate-Specific Membrane Antigen-Targeted Radiohalogenated PET and Therapeutic Agents for Prostate Cancer.

Steven P Rowe, Alexander Drzezga, Bernd Neumaier, Markus Dietlein, Michael A Gorin, Michael R Zalutsky, Martin G Pomper

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 54 citations in OpenAlex.

  1. Prostate Specific Membrane Antigen TargetedThe Journal of urology · 2018
    Trial
  2. Review
  3. Modular Smart Molecules for PSMA-Targeted Chemotherapy.Molecular cancer therapeutics · 2022
    Article
  4. Article
  5. Review
  6. Frontiers in oncology · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Theranostics · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Molecular imaging of prostate cancer.The British journal of radiology · 2018
    Review
  16. Review
  17. Low levels of PSMA expression limit the utility ofAnnals of nuclear medicine · 2018
    Article
  18. Article
  19. Article
  20. Radiotheranostics in Prostate Cancer: Introduction and Overview.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Steven P RoweThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Alexander DrzezgaDepartment of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany.
Bernd NeumaierInstitute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany.
Markus DietleinDepartment of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany.
Michael A GorinThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and.
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, North Carolina.
Martin G PomperThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland mpomper@jhmi.edu.
Johns Hopkins University · USUniversity Hospital Cologne · DEDuke Medical Center · US

Funding

PSMA-based Cancer Imaging AgentsR01CA134675 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G · 2009 to 2025
$6.2M
Small Molecule PSMA-Targeted Alpha TherapyR01CA184228 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G, ZALUTSKY, MICHAEL ROD · 2014 to 2023
$3.6M
NCI NIH HHS R01 CA134675NCI NIH HHS R01 CA184228
6 · The paper itself

Abstract

Radiohalogenated agents are often the first line of pursuit in the development of new radiopharmaceuticals-whether antibodies, peptides, or small molecules-because of their ease of synthesis, lack of substantial steric perturbation of the original affinity agent (in some cases, providing enhanced affinity), and capacity to be transformed into therapeutics (in some cases, with a mere switch of an isotope). They often provide proof of a principle before optimization for pharmacokinetics or generation of radiometallated agents, when the latter are necessary. In particular,

Indexed as

Positron-Emission TomographyEvidence-Based MedicineHalogensHumansImage EnhancementMaleMolecular Probe TechniquesMolecular Targeted TherapyProstate-Specific AntigenProstatic NeoplasmsRadioisotopesRadiopharmaceuticalsTreatment OutcomeHalogensProstate-Specific AntigenRadioisotopesRadiopharmaceuticals18F211Atbiochemical recurrencePETprostate-specific membrane antigen

Identifiers

PMID27694179
PMCPMC5093916
OpenAlexW2526522995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.