ArticleVirus research2017
Differential response of cassava genotypes to infection by cassava mosaic geminiviruses.
Article in Virus research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Allelic differences within DNA polymerase delta subunit 1 correlate with geminivirus resistance in diverse plants.G3 (Bethesda, Md.) · 2025Article
- Review
- Article
- Investigating Grapevine Red Blotch Virus Infection inInternational journal of molecular sciences · 2022Article
- Advances in Genetic Analysis and Breeding of Cassava (Plants (Basel, Switzerland) · 2022Review
- Deeply Sequenced Infectious Clones of Key Cassava Begomovirus Isolates from Cameroon.Microbiology resource announcements · 2020Article
- Evaluation of cultural control and resistance-breeding strategies for suppression of whitefly infestation of cassava at the landscape scale: a simulation modeling approach.Pest management science · 2020Article
- Geminivirus Resistance: A Minireview.Frontiers in plant science · 2020Review
- RNA silencing ofBiotechnology reports (Amsterdam, Netherlands) · 2019Article
- Evaluation of resistance to cassava mosaic disease in selected African cassava cultivars using combined molecular and greenhouse grafting tools.Physiological and molecular plant pathology · 2019Article
- Response of cassava cultivars to African cassava mosaic virus infection across a range of inoculum doses and plant ages.PloS one · 2019Article
- A guide to the contained use of plant virus infectious clones.Plant biotechnology journal · 2018Review
- A rapid virus-induced gene silencing (VIGS) method for assessing resistance and susceptibility to cassava mosaic disease.Virology journal · 2017Article
- The Search for Resistance to Cassava Mosaic Geminiviruses: How Much We Have Accomplished, and What Lies Ahead.Frontiers in plant science · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitigation of cassava mosaic disease (CMD) focuses on the introgression of resistance imparted by the polygenic recessive (CMD1), dominant monogenic (CMD2) and CMD3 loci. The mechanism(s) of resistance they impart, however, remain unknown. Two CMD susceptible and nine CMD resistant cassava genotypes were inoculated by microparticle bombardment with infectious clones of African cassava mosaic virus Cameroon strain (ACMV-CM) and the Kenyan strain K201 of East African cassava mosaic virus (EACMV KE2 [K201]). Genotypes carrying the CMD1 (TMS 30572), CMD2 (TME 3, TME 204 and Oko-iyawo) and CMD3 (TMS 97/0505) resistance mechanisms showed high levels of resistance to ACMV-CM, with viral DNA undetectable by PCR beyond 7days post inoculation (dpi). In contrast, all genotypes initially developed severe CMD symptoms and accumulated high virus titers after inoculation with EACMV KE2 (K201). Resistant genotypes recovered to become asymptomatic by 65dpi with no detectable virus in newly formed leaves. Genotype TMS 97/2205 showed highest resistance to EACMV KE2 (K201) with <30% of inoculated plants developing symptoms followed by complete recovery by 35dpi. Deep sequencing of small RNAs confirmed production of 21-24 nt virus derived small RNAs (vsRNA) that mapped to cover the entire ACMV-CM and EACMV KE2 (K201) viral genomes in both polarities, with hotspots seen within gene coding regions. In resistant genotypes, total vsRNAs were most abundant at 20 and 35dpi but reduced significantly upon recovery from CMD. In contrast, CMD susceptible genotypes displayed abundant vsRNAs throughout the experimental period. The percentage of vsRNAs reads ranked by class size were 21nt (45%), 22 nt (28%) and 24 nt (18%) in all genotypes studied. The number of vsRNA reads directly correlated with virus titer and CMD symptoms.
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