Evidence map›Paper›PMID 27693830›Full record

ReviewAgeing research reviews2017

Nutrition and other lifestyle influences on arterial aging.

Thomas J LaRocca, Christopher R Martens, Douglas R Seals

Abstract readReview
In one paragraph

Review in Ageing research reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Article
  9. The impact of age and sex on cerebral and large artery stiffness and the response to pulse pressure.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  10. [Effects of Multiple Lifestyle Factors on Cardiovascular Biological Aging and Their Relative Contributions].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
  11. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas J LaRoccaDepartment of Integrative Physiology, University of Colorado Boulder, 354 UCB, Boulder, CO 80309, USA. Electronic address: thomas.larocca@colorado.edu.
Christopher R MartensDepartment of Integrative Physiology, University of Colorado Boulder, 354 UCB, Boulder, CO 80309, USA.
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, 354 UCB, Boulder, CO 80309, USA.

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
University of Colorado Aging Training GrantT32AG000279 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2001 to 2026
$10.1M
Weight Loss, Inflammation, and Vascular Endothelial Function in Older AdultsR01AG006537 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 1986 to 2010
$4.4M
SODIUM RESTRICTION &ARTERIAL COMPLIANCE IN OLDER HUMANSR01AG013038 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 1996 to 2018
$4.0M
TDP-43, RNA Metabolism, and ALS/FTD PathologyR01NS063964 · NINDS · UNIVERSITY OF COLORADO · PI LINK, CHRISTOPHER D. · 2009 to 2019
$3.5M
Human Aging, Exercise &FMD: Translational PhysiologyR37AG013038 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 2004 to 2013
$3.0M
NCATS NIH HHS UL1 TR001082NIA NIH HHS R01 AG006537NIA NIH HHS R01 AG013038NIA NIH HHS R37 AG013038NIA NIH HHS T32 AG000279NIDDK NIH HHS P30 DK048520NINDS NIH HHS R01 NS063964
6 · The paper itself

Abstract

As our world's population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial function. Accumulating evidence demonstrates that diet and nutrition may favorably modulate these arterial functions with aging, but many important questions remain. In this review, we will summarize the available information on dietary patterns and nutritional factors that have been studied for their potential to reduce arterial stiffness and improve endothelial function with age, with an emphasis on: 1) underlying physiological mechanisms, and 2) emerging areas of research on nutrition and arterial aging that may hold promise for preventing age-related CVD.

Indexed as

Diet TherapyHealthy AgingAgingArteriesCardiovascular DiseasesDietEndothelium, VascularHumansLife StyleNutritional StatusRisk FactorsVascular StiffnessArterial stiffnessDietEndothelial dysfunctionNutrition

Identifiers

PMID27693830
PMCPMC5373983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.