ArticleNuclear medicine and biology2016
Facile room temperature synthesis of fluorine-18 labeled fluoronicotinic acid-2,3,5,6-tetrafluorophenyl ester without azeotropic drying of fluorine-18.
Article in Nuclear medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
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- Precision radiolabeled B-cell maturation nanobody for targeted PET imaging and radioligand therapy of disseminated multiple myeloma.Theranostics · 2026Article
- Monitoring T-Cell Activation in the Tumor Microenvironment by PET Imaging of the Chemokine CXCL9.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Radiosynthesis, structural identification and in vitro tissue binding study of [EJNMMI radiopharmacy and chemistry · 2024Article
- 7-[Journal of medicinal chemistry · 2023Article
- Next Generation Copper Mediators for the Efficient Production ofChemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- A new automated and putatively versatile synthesis of the PSMA-ligand derivative [EJNMMI radiopharmacy and chemistry · 2022Article
- High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis.The Journal of clinical investigation · 2022Article
- Article
- Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain.ACS chemical neuroscience · 2020Article
- Automated Synthesis of Fluorine-18 Labeled CXCR4 Ligand via the Conjugation with Nicotinic AcidMolecules (Basel, Switzerland) · 2020Article
- A non-anhydrous, minimally basic protocol for the simplification of nucleophilicScientific reports · 2020Article
- ImmunoPET: Concept, Design, and Applications.Chemical reviews · 2020Review
- Fluorine-18 Labeled Fluorofuranylnorprogesterone ([Molecules (Basel, Switzerland) · 2019Article
- Fully automated peptide radiolabeling from [RSC advances · 2019Article
- An azeotropic drying-free approach for copper-mediated radiofluorination without addition of base.Journal of labelled compounds & radiopharmaceuticals · 2019Article
- Labeling Single Domain Antibody Fragments with Fluorine-18 Using 2,3,5,6-Tetrafluorophenyl 6-[Molecular pharmaceutics · 2019Article
- Rapid synthesis of maleimide functionalized fluorine-18 labeled prosthetic group using "radio-fluorination on the Sep-Pak" method.Journal of labelled compounds & radiopharmaceuticals · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Fluorine-18 labeled fluoronicotinic acid-2,3,5,6-tetrafluorophenyl ester has been successfully synthesized in an unprecedented way by flowing an acetonitrile solution of its quaternary ammonium salt precursor (N,N,N-trimethyl-5-((2,3,5,6-tetrafluorophenoxy)carbonyl)pyridin-2-aminium trifluoromethanesulfonate, 1) through an anion exchange cartridge. The fluorination reaction proceeded at room temperature without azeotropic drying of the fluoride. Over 75% conversion was observed with 10mg of precursor in 2:8, acetonitrile: t-butanol in 1min. The total synthesis time was 5min which is ~30min shorter than the current literature method.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.