ArticleMolecular and cellular endocrinology2017
Gene expression profiling of bovine ovarian follicular and luteal cells provides insight into cellular identities and functions.
Article in Molecular and cellular endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Developmental and functional landscape of theca cells in ovarian biology.Biological research · 2026Review
- Bovine Corpus Luteum Proteomics during Different Reproductive and Physiological Stages.Scientific data · 2026Article
- PDK4 is critical for metabolic regulation and progesterone production in bovine granulosa cells†.Biology of reproduction · 2026Article
- New Insights into the Mechanism of Insulin-like Peptide 3 (International journal of molecular sciences · 2025Article
- Article
- Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development.Biological research · 2024Article
- Unraveling the role of lipid droplets and perilipin 2 in bovine luteal cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Saturated fatty acids inhibit unsaturated fatty acid induced glucose uptake involving GLUT10 and aerobic glycolysis in bovine granulosa cells.Scientific reports · 2024Article
- Puberty classifications in beef heifers are moderately to highly heritable and associated with candidate genes related to cyclicity and timing of puberty.Frontiers in genetics · 2024Article
- Prostaglandin F2α regulates mitochondrial dynamics and mitophagy in the bovine corpus luteum.Life science alliance · 2023Article
- Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal mouse ovaries.Toxicology and applied pharmacology · 2022Article
- Follicular Hyperstimulation Dysgenesis: New Explanation for Adverse Effects of Excessive FSH in Ovarian Stimulation.Endocrinology · 2022Article
- Transcriptome analysis reveals transforming growth factor-β1 prevents extracellular matrix degradation and cell adhesion during the follicular-luteal transition in cows.The Journal of reproduction and development · 2022Article
- Use of Agriculturally Important Animals as Models in Biomedical Research.Advances in experimental medicine and biology · 2022Review
- Dynamic patterns of expressed genes in granulosa cells during follicular and luteal stages in Egyptian buffaloes.Tropical animal health and production · 2021Article
- Transcriptomic data of bovine ovarian granulosa cells of control and High A4 cows.Data in brief · 2021Article
- A high-androgen microenvironment inhibits granulosa cell proliferation and alters cell identity.Molecular and cellular endocrinology · 2021Article
- Attainment and maintenance of pubertal cyclicity may predict reproductive longevity in beef heifers†.Biology of reproduction · 2021Article
- Prostaglandin F2 Alpha Triggers the Disruption of Cell Adhesion with Cytokeratin and Vimentin in Bovine Luteal Theca Cells.Animals : an open access journal from MDPI · 2021Article
- miR-4463 regulates aromatase expression and activity for 17β-estradiol synthesis in response to follicle-stimulating hormone.Clinical and experimental reproductive medicine · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
After ovulation, somatic cells of the ovarian follicle (theca and granulosa cells) become the small and large luteal cells of the corpus luteum. Aside from known cell type-specific receptors and steroidogenic enzymes, little is known about the differences in the gene expression profiles of these four cell types. Analysis of the RNA present in each bovine cell type using Affymetrix microarrays yielded new cell-specific genetic markers, functional insight into the behavior of each cell type via Gene Ontology Annotations and Ingenuity Pathway Analysis, and evidence of small and large luteal cell lineages using Principle Component Analysis. Enriched expression of select genes for each cell type was validated by qPCR. This expression analysis offers insight into cell-specific behaviors and the differentiation process that transforms somatic follicular cells into luteal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.