Evidence map›Paper›PMID 27693434›Full record

ArticleDevelopmental biology2017

Distinct regulation of atonal in a visual organ of Drosophila: Organ-specific enhancer and lack of autoregulation in the larval eye.

Qingxiang Zhou, Linlin Yu, Markus Friedrich, Francesca Pignoni

Abstract read
In one paragraph

Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Qingxiang ZhouDepartment of Ophthalmology and Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY, USA.
Linlin YuDepartment of Ophthalmology and Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY, USA.
Markus FriedrichDepartment of Biological Sciences, Wayne State University, Detroit, MI 48202, USA; Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USA.
Francesca PignoniDepartment of Ophthalmology and Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY, USA; Departments of Neuroscience & Physiology and Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA. Electronic address: PignoniF@Upstate.edu.

Funding

GENETIC CONTROL OF EYE SPECIFICATIONR01EY013167 · NEI · UPSTATE MEDICAL UNIVERSITY · PI PIGNONI, FRANCESCA · 2000 to 2010
$2.9M
Role of Microphthalmia/MITF Factor in Eye DevelopmentR01EY017097 · NEI · UPSTATE MEDICAL UNIVERSITY · PI PIGNONI, FRANCESCA · 2007 to 2011
$1.7M
NEI NIH HHS R01 EY013167NEI NIH HHS R01 EY017097
6 · The paper itself

Abstract

Drosophila has three types of visual organs, the larval eyes or Bolwig's organs (BO), the ocelli (OC) and the compound eyes (CE). In all, the bHLH protein Atonal (Ato) functions as the proneural factor for photoreceptors and effects the transition from progenitor cells to differentiating neurons. In this work, we investigate the regulation of ato expression in the BO primordium (BOP). Surprisingly, we find that ato transcription in the BOP is entirely independent of the shared regulatory DNA for the developing CE and OC. The core enhancer for BOP expression, ato

Indexed as

Enhancer Elements, GeneticGene Expression Regulation, Developmental5' Flanking RegionAnimalsBase SequenceBasic Helix-Loop-Helix ProteinsBinding SitesDNADrosophila melanogasterDrosophila ProteinsEyeEye ProteinsHomeodomain ProteinsHomeostasisLarvaNerve Tissue Proteinsato protein, DrosophilaBasic Helix-Loop-Helix ProteinsDNADrosophila ProteinsEye ProteinsHomeodomain ProteinsNerve Tissue ProteinsSo protein, DrosophilaAth5Atoh7Eye evolutionNeurogenesisRDGNRDN

Identifiers

PMID27693434
PMCPMC5358805

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.