Evidence map›Paper›PMID 27693401›Full record

ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2016

Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border.

Bhavna Gupta, Daniel M Parker, Qi Fan, B P Niranjan Reddy, Guiyun Yan, Jetsumon Sattabongkot, Liwang Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Distinct Allelic Diversity ofJournal of tropical medicine · 2023
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bhavna GuptaDepartment of Entomology, Pennsylvania State University, University Park, PA 16802, USA. Electronic address: bhavnaguptaster@gmail.com.
Daniel M ParkerDepartment of Entomology, Pennsylvania State University, University Park, PA 16802, USA; Shoklo Malaria Research Unit, Mahidol-Oxford Tropic al Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Tak, Thailand. Electronic address: daniel@shoklo-unit.com.
Qi FanDalian Institute of Biotechnology, Dalian, Liaoning Province, China. Electronic address: qifan10001@163.com.
B P Niranjan ReddyDepartment of Entomology, Pennsylvania State University, University Park, PA 16802, USA. Electronic address: bp.niranjanreddy@gmail.com.
Guiyun YanProgram in Public Health, University of California Irvine, Irvine, CA, USA. Electronic address: guiyuny@uci.edu.
Jetsumon SattabongkotMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. Electronic address: jetsumon.pra@mahidol.edu.
Liwang CuiDepartment of Entomology, Pennsylvania State University, University Park, PA 16802, USA. Electronic address: luc2@psu.edu.

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
NCATS NIH HHS UL1 TR001414NIAID NIH HHS U19 AI089672
6 · The paper itself

Abstract

Malaria transmission along international borders of the Greater Mekong Subregion is a big challenge for regional malaria elimination. At the Thai-Myanmar border, Plasmodium falciparum cases have dropped dramatically; however, increasing P. vivax prevalence and the emerging reports on hidden malaria burden due to asymptomatic infections demand attention. We conducted cross-sectional surveys to detect asymptomatic malaria infections in a small village located at Thai-Myanmar border and genotyped P. vivax infections in order to understand the level of genetic diversity on such a microgeographic scale. PCR/RFLP and DNA sequencing identified high levels of genetic polymorphisms at both Pvmsp3α and Pvmsp3β loci among P. vivax infections. Combining the PCR/RFLP patterns of Pvmsp3α and Pvmsp3β, a total of 10 genotypes were observed among 17 samples, while concatenated DNA sequences of Pvmsp3α and 3β generated 14 haplotypes with haplotype diversity of 0.97. These markedly diverse parasites on a microgeographic scale suggest the circulation of a considerably large parasite population at the international border.

Indexed as

AdolescentAdultAntigens, ProtozoanAsymptomatic InfectionsChildChild, PreschoolCross-Sectional StudiesDNA, ProtozoanFemaleGenetic VariationHaplotypesHumansInfantMalaria, VivaxMaleMiddle AgedAntigens, ProtozoanDNA, Protozoanmerozoite surface protein 3betaGenetic diversityMicrogeographicPlasmodium vivaxPvmsp3αPvmsp3βThai-Myanmar

Identifiers

PMID27693401
PMCPMC5123908

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.