Evidence map›Paper›PMID 27693258›Full record

ArticleNeuron2016

Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons.

Jie Zhang, Chase M Carver, Frank S Choveau, Mark S Shapiro

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
12.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
  2. A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. KAddiction biology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Voltage sensors of a NaNature communications · 2023
    Article
  10. Article
  11. Clustering of CaJournal of neurochemistry · 2023
    Article
  12. Unique features of the arterial blood-brain barrier.Fluids and barriers of the CNS · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jie ZhangDepartment of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Chase M CarverDepartment of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Frank S ChoveauDepartment of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Mark S ShapiroDepartment of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address: shapirom@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · US

Funding

PATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9M
Modulation of Neuronal Ion Channels by 2nd MessengersR01NS043394 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2002 to 2014
$4.5M
Targeting specific interactions between A-kinase Anchoring Proteins (AKAPs) and ion channels with cell-permeant peptides as a novel mode of therapeutic intervention against pain disordersR01NS094461 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2015 to 2019
$2.0M
Mechanism and functional role of AKAP79/150 in M current control and excitabilityR01NS065138 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2009 to 2010
$788k
Mechanism and functional role of AKAP79/150 in M current controlR56NS065138 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHAPIRO, MARK S · 2012 to 2012
$465k
NHLBI NIH HHS T32 HL007446NINDS NIH HHS R01 NS043394NINDS NIH HHS R01 NS065138NINDS NIH HHS R01 NS094461NINDS NIH HHS R56 NS065138
6 · The paper itself

Abstract

The fidelity of neuronal signaling requires organization of signaling molecules into macromolecular complexes, whose components are in intimate proximity. The intrinsic diffraction limit of light makes visualization of individual signaling complexes using visible light extremely difficult. However, using super-resolution stochastic optical reconstruction microscopy (STORM), we observed intimate association of individual molecules within signaling complexes containing ion channels (M-type K

Indexed as

A Kinase Anchor ProteinsAnimalsCalcium Channels, L-TypeCHO CellsCricetulusFluorescent Antibody TechniqueHumansKCNQ2 Potassium ChannelKCNQ3 Potassium ChannelMicroscopyMultiprotein ComplexesNeuronsOptical ImagingReceptors, G-Protein-CoupledTRPV Cation ChannelsAKAP5 protein, humanA Kinase Anchor ProteinsCalcium Channels, L-TypeKCNQ2 Potassium ChannelKCNQ3 Potassium ChannelL-type calcium channel alpha(1C)Multiprotein ComplexesReceptors, G-Protein-CoupledTRPV1 protein, humanTRPV Cation ChannelsA-kinase anchoring proteinsion channelspotassium channelssuper-resolution microscopy

Identifiers

PMID27693258
PMCPMC5553284
OpenAlexW2526241242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.