Evidence map›Paper›PMID 27693197›Full record

ArticleNeuroImage2017

Multiparametric imaging of brain hemodynamics and function using gas-inhalation MRI.

Peiying Liu, Babu G Welch, Yang Li, Hong Gu, Darlene King, Yihong Yang, Marco Pinho, Hanzhang Lu

Abstract read
In one paragraph

Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Separating vascular and neuronal effects of age on fMRI BOLD signals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Brain BOLD MRI OCritical care (London, England) · 2020
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peiying LiuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Babu G WelchDepartment of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX 75390, United States; Department of Radiology, UT Southwestern Medical Center, Dallas, TX 75390, United States.
Yang LiDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Biomedical Engineering Graduate Program, UT Southwestern Medical Center, Dallas, TX 75390, United States.
Hong GuNeuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, United States.
Darlene KingDepartment of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX 75390, United States.
Yihong YangNeuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, United States.
Marco PinhoDepartment of Radiology, UT Southwestern Medical Center, Dallas, TX 75390, United States.
Hanzhang LuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States. Electronic address: hanzhang.lu@jhu.edu.

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
Normalized functional MRI in human brain disordersR01MH084021 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2008 to 2017
$3.6M
Cognition and cerebrovascular function across the lifespanR01AG042753 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2013 to 2015
$841k
Advanced MRI methods to image vascular physiology with respiratory manipulationsR21NS095342 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2016 to 2017
$476k
Quantification of brain metabolic rate in neonates using MRIR21NS085634 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LIU, PEIYING · 2014 to 2015
$441k
NIA NIH HHS P50 AG005146NIA NIH HHS R01 AG042753NIMH NIH HHS R01 MH084021NINDS NIH HHS R21 NS085634NINDS NIH HHS R21 NS095342
6 · The paper itself

Abstract

Diagnosis and treatment monitoring of cerebrovascular diseases routinely require hemodynamic imaging of the brain. Current methods either only provide part of the desired information or require the injection of multiple exogenous agents. In this study, we developed a multiparametric imaging scheme for the imaging of brain hemodynamics and function using gas-inhalation MRI. The proposed technique uses a single MRI scan to provide simultaneous measurements of baseline venous cerebral blood volume (vCBV), cerebrovascular reactivity (CVR), bolus arrival time (BAT), and resting-state functional connectivity (fcMRI). This was achieved with a novel, concomitant O

Indexed as

HemodynamicsMagnetic Resonance ImagingAdultBrainBrain MappingCarbon DioxideFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedMoyamoya DiseaseOxygenSignal Processing, Computer-AssistedYoung AdultCarbon DioxideOxygenBolus arrival timeCerebrovascular reactivityHypercapniaHyperoxiaResting-state functional connectivityVenous cerebral blood volume

Identifiers

PMID27693197
PMCPMC5322044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.