Evidence map›Paper›PMID 27693026›Full record

ArticleThe journal of allergy and clinical immunology. In practice

Hemoptysis in a Patient with Elevated Immunoglobulin E.

Yael Gernez, Angela Tsuang, Tukisa D Smith, Khurram Shahjehan, Yiqun Hui, Paul J Maglione, Charlotte Cunningham-Rundles

Open access · greenAbstract readCase Reports
In one paragraph

Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Inherited human ZNF341 deficiency.Current opinion in immunology · 2023
    Review
  4. Review
  5. Review
  6. Primary Immunodeficiency: New Insights and Practical Clinical Approaches.The journal of allergy and clinical immunology. In practice
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yael GernezDivision of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Angela TsuangDivision of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Tukisa D SmithDivision of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Khurram ShahjehanDivision of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine, Mount Sinai, New York, NY.
Yiqun HuiDivision of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Paul J MaglioneDivision of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY.
Charlotte Cunningham-RundlesDivision of Allergy and Clinical Immunology, Icahn School of Medicine, Mount Sinai, New York, NY. Electronic address: charlotte.cunningham-rundles@mssm.edu.
Icahn School of Medicine at Mount Sinai · US

Funding

Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8M
Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)U24AI086037 · NIAID · IMMUNE DEFICIENCY FOUNDATION · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2010 to 2019
$6.5M
NIAID NIH HHS P01 AI061093NIAID NIH HHS U24 AI086037
6 · The paper itself

Abstract

Recurrent pneumonia with cavitation leading to pneumatoceles, secondary fungal infections, and hemoptysis are major causes of mortality and morbidity in patients with hyper-IgE syndrome. Prevention and aggressive treatment of pneumonia in these patients are essential to prevent further lung damage, but treatment may be delayed because the classic signs/symptoms of infection such as fever, chills, or rigors may be lacking. Early imaging to identify infection is essential for diagnosis and treatment. The mainstay of therapy is continuous, full-dose daily trimethoprim-sulfamethoxazole and commonly fungal coverage. Because hyper-IgE syndrome is a progressive disease, patients' condition may worsen despite compliance with prophylactic therapy.

Indexed as

AdultHemoptysisHumansImmunoglobulin ELungMaleRadiographyYoung AdultImmunoglobulin EAspergillomaEczemahyper-IgE syndromeImmunodeficiencySTAT3

Identifiers

PMID27693026
PMCPMC5322743
OpenAlexW2527368952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.