ArticleThe Journal of thoracic and cardiovascular surgery2016
Does moderate hypothermia really carry less bleeding risk than deep hypothermia for circulatory arrest? A propensity-matched comparison in hemiarch replacement.
Article in The Journal of thoracic and cardiovascular surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Effect of Deep Hypothermic Circulatory Arrest Versus Moderate Hypothermic Circulatory Arrest in Aortic Arch Surgery on Postoperative Renal Function: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- Organ protection via core temperature control in Type A aortic dissection using pure hypothermia alone.Journal of cardiothoracic surgery · 2026Article
- Total Arch With Hybrid Frozen Elephant Trunk Versus Branched Stented Anastomosis Frozen Elephant Trunk Repair.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Cerebral and Spinal Cord Protection Strategies in Aortic Arch Surgery.Journal of cardiovascular development and disease · 2025Review
- Impact of Cooling Strategies on Transfusion Requirements in Aortic Hemiarch Surgery.Aorta (Stamford, Conn.) · 2025Article
- Hypothermic circulatory arrest at 20 ℃ does not deteriorate coagulopathy compared to 28 ℃ in a pig model.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Cerebral protection: Antegrade cerebral perfusion in the modern era. Does temperature matter?JTCVS techniques · 2024Article
- Short-term outcomes of mild (≥30 ℃)Journal of thoracic disease · 2024Article
- Hypothermic circulatory arrest does not induce coagulopathy in vitro.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2022Article
- Article
- Comparison of short-term outcomes of mild and moderate hypothermic circulatory arrest in aortic arch surgery: a single center retrospective cohort study.Annals of translational medicine · 2022Article
- Recombinant Activated Factor VII in Aortic Surgery for Patients Under Hypothermic Circulatory Arrest.Therapeutics and clinical risk management · 2022Article
- Risk factor analysis of clinical outcomes of total aortic arch replacement and frozen elephant trunk with aortic balloon occlusion.Journal of cardiothoracic surgery · 2021Article
- Modified Technique for Retrograde Cerebral Perfusion during Hemiarch Aortic Replacement.Aorta (Stamford, Conn.) · 2021Article
- Short-Periods of Pre-Warming in Laparoscopic Surgery. A Non-Randomized Clinical Trial Evaluating Current Clinical Practice.Journal of clinical medicine · 2021Article
- Mild hypothermic circulatory arrest with selective cerebral perfusion in open arch surgery.Journal of thoracic disease · 2021Article
- Hypothermic circulatory arrest induced coagulopathy: rotational thromboelastometry analysis.General thoracic and cardiovascular surgery · 2020Observational
- Aortic valve repair with a newly approved geometric annuloplasty ring in patients undergoing proximal aortic repair: early results from a single-centre experience.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2020Article
- Renal protective effect of the aortic balloon occlusion technique in total arch replacement with frozen elephant trunk.Annals of cardiothoracic surgery · 2020Article
- Low molecular weight heparin in surgical valve procedures: When and how much for an optimal prophylaxis?Cardiology journal · 2020Article
Corrections and comments
- Commented on byDiscussion.2016
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundModerate (MHCA) versus deep (DHCA) hypothermia for circulatory arrest in aortic arch surgery has been purported to reduce coagulopathy and bleeding complications, although there are limited data supporting this claim. This study aimed to compare bleeding-related events after aortic hemiarch replacement with MHCA versus DHCA.
methodsPatients who underwent hemiarch replacement at a single institution from July 2005 to August 2014 were stratified into DHCA and MHCA groups (minimum systemic temperature ≤20°C and >20°C, respectively) and compared. Then, 1:1 propensity matching was performed to adjust for baseline differences.
resultsDuring the study period, 571 patients underwent hemiarch replacement: 401 (70.2%) with DHCA and 170 (29.8%) with MHCA. After propensity matching, 155 patients remained in each group. There were no significant differences between matched groups with regard to the proportion transfused with red blood cells, plasma, platelet concentrates, or cryoprecipitate on the operative day, the rate of reoperation for bleeding, or postoperative hematologic laboratory values. Among patients who received plasma, the median transfusion volume was statistically greater in the DHCA group (6 vs 5 units, P = .01). MHCA also resulted in a slight reduction in median volume of blood returned via cell saver (500 vs 472 mL, P < .01) and 12-hour postoperative chest tube output (440 vs 350, P < .01). Thirty-day mortality and morbidity did not differ significantly between groups.
conclusionsMHCA compared with DHCA during hermiarch replacement may slightly reduce perioperative blood-loss and plasma transfusion requirement, although these differences do not translate into reduced reoperation for bleeding or postoperative mortality and morbidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.