Evidence map›Paper›PMID 27692806›Full record

ArticleKidney international2017

Human vascular progenitor cells derived from renal arteries are endothelial-like and assist in the repair of injured renal capillary networks.

Paul Pang, Molly Abbott, Steven L Chang, Malyun Abdi, Nikita Chauhan, Murti Mistri, Joshua Ghofrani, Quynh-Anh Fucci, Colleen Walker, Corey Leonardi and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  8. Review
  9. UAB-UCSD O'Brien Center for Acute Kidney Injury Research.American journal of physiology. Renal physiology · 2021
    Review
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  11. Article
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  13. Article
  14. Article
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  17. New insight into the role of extracellular vesicles in kidney disease.Journal of cellular and molecular medicine · 2019
    Review
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  20. Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 1 country.

Paul PangDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Molly AbbottDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Steven L ChangUrology Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Malyun AbdiDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nikita ChauhanDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Murti MistriDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Joshua GhofraniDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Quynh-Anh FucciDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Colleen WalkerDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Corey LeonardiDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Samuel GradyDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Arvin HalimInternal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ryan HoffmanInternal Medicine, Touro College of Osteopathic Medicine, New York, NY, USA.
Tzongshi LuInternal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Huixia CaoInternal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Stefan G TulliusTransplant Surgery Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sayeed MalekTransplant Surgery Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sanjaya KumarTransplant Surgery Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Graeme SteeleUrology Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Adam KibelUrology Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Benjamin S FreedmanDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Sushrut S WaikarDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Andrew M SiedleckiDepartment of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: asiedlecki@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USTouro College · USUniversity of Washington · US

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
Biomarkers of Kidney PathologyR01DK093574 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI WAIKAR, SUSHRUT S. · 2012 to 2015
$2.4M
Novel Human Biomarkers of Kidney FibrosisU01DK104308 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HUMPHREYS, BENJAMIN D., WAIKAR, SUSHRUT S. · 2014 to 2018
$2.0M
THE ROLE OF REGULATOR OF G-PROTEIN SIGNALING 4 IN ACUTE KIDNEY INJURYK08DK089002 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SIEDLECKI, ANDREW MICHAEL · 2011 to 2015
$795k
Modeling Polycystic Kidney Disease Using Human Induced Pluripotent Stem CellsK01DK102826 · NIDDK · UNIVERSITY OF WASHINGTON · PI FREEDMAN, BENJAMIN SOLOMON · 2014 to 2018
$743k
NIDDK NIH HHS K01 DK102826NIDDK NIH HHS K08 DK089002NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK093574NIDDK NIH HHS U01 DK104308
6 · The paper itself

Abstract

Vascular progenitor cells show promise for the treatment of microvasculature endothelial injury. We investigated the function of renal artery progenitor cells derived from radical nephrectomy patients, in animal models of acute ischemic and hyperperfusion injuries. Present in human adventitia, CD34positive/CD105negative cells were clonal and expressed transcription factors Sox2/Oct4 as well as surface markers CXCR4 (CD184)/KDR(CD309) consistent with endothelial progenitor cells. Termed renal artery-derived vascular progenitor cells (RAPC), injected cells were associated with decreased serum creatinine after ischemia/reperfusion, reduced albuminuria after hyperperfusion, and improved blood flow in both models. A small population of RAPC integrated with the renal microvasculature following either experimental injury. At a cellular level, RAPC promoted local endothelial migration in co-culture. Profiling of RAPC microRNA identified high levels of miRNA 218; also found at high levels in exosomes isolated from RAPC conditioned media after cell contact for 24 hours. After hydrogen peroxide-induced endothelial injury, RAPC exosomes harbored Robo-1 transcript; a gene known to be regulated by mir218. Such exosomes enhanced endothelial cell migration in culture in the absence of RAPC. Thus, our work shows the feasibility of pre-emptive pro-angiogenic progenitor cell procurement from a targeted patient population and potential therapeutic use in the form of autologous cell transplantation.

Indexed as

Wound HealingAcute Kidney InjuryAnimalsAntigens, CD34CapillariesCell MovementCoculture TechniquesCreatinineDisease Models, AnimalEndoglinEndotheliumExosomesFeasibility StudiesHumansHydrogen PeroxideKidneyAntigens, CD34CreatinineCXCR4 protein, humanEndoglinHydrogen PeroxideKDR protein, humanMicroRNAsMIRN218 microRNA, humanNerve Tissue ProteinsReceptors, CXCR4Receptors, ImmunologicRoundabout ProteinsVascular Endothelial Growth Factor Receptor-2acute kidney injuryendotheliumhyperfiltrationischemia reperfusionstem cell

Identifiers

PMID27692806
PMCPMC5179298
OpenAlexW2527005326

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.