ArticleOphthalmology2016
Pediatric Idiopathic Intracranial Hypertension: Age, Gender, and Anthropometric Features at Diagnosis in a Large, Retrospective, Multisite Cohort.
Article in Ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- Diagnostic value of machine-learning using conventional magnetic resonance imaging markers for pediatric idiopathic intracranial hypertension: a retrospective study.Pediatric radiology · 2026Article
- Article
- Idiopathic Intracranial Hypertension in Children and Adolescents with Obesity: A Narrative Review.Children (Basel, Switzerland) · 2025Review
- Paediatric IIH: Are There Differences in Visual Outcomes and Recurrence Rates?Neuro-ophthalmology (Aeolus Press) · 2025Article
- Clinical and Radiological Characteristics of Non-Obese Female Patients with Idiopathic Intracranial Hypertension.Journal of clinical medicine · 2024Article
- Different Characteristics of Pre-Pubertal and Post-Pubertal Idiopathic Intracranial Hypertension: A Narrative Review.Neuro-ophthalmology (Aeolus Press) · 2023Review
- Improving pediatric idiopathic intracranial hypertension care: a retrospective cohort study.Scientific reports · 2022Article
- Review
- Effects of acetazolamide on linear growth in children with pseudotumor cerebri syndrome.Frontiers in ophthalmology · 2022Article
- Autism Spectrum Disorder in Pediatric Idiopathic Intracranial Hypertension.Life (Basel, Switzerland) · 2021Article
- Paediatric Idiopathic Intracranial Hypertension (IIH)-A Review.Life (Basel, Switzerland) · 2021Review
- Update on the Classification and Pathophysiological Mechanisms of Pediatric Cardiorenal Syndromes.Children (Basel, Switzerland) · 2021Review
- Idiopathic Intracranial Hypertension: Evaluation of Admissions and Emergency Readmissions through the Hospital Episode Statistic Dataset between 2002-2020.Life (Basel, Switzerland) · 2021Article
- Reviewing the Recent Developments in Idiopathic Intracranial Hypertension.Ophthalmology and therapy · 2020Review
- The incidence of obesity, venous sinus stenosis and cerebral hyperaemia in children referred for MRI to rule out idiopathic intracranial hypertension at a tertiary referral hospital: a 10 year review.Fluids and barriers of the CNS · 2020Article
- Sleep disturbance in pediatric intracranial hypertension.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Observational
- Pseudotumor Cerebri Syndrome in Children.Current pain and headache reports · 2019Review
- 14th EUNOS Congress: PORTO, PORTUGAL, 16-19 JUNE 2019.Neuro-ophthalmology (Aeolus Press) · 2019Article
- Demographics, clinical features, and response to conventional treatments in pediatric Pseudotumor Cerebri syndrome: a single-center experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Article
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Authors and funding
13 authors at 10 institutions in 5 countries.
Funding
Abstract
purposeTo examine anthropometric and maturational characteristics at diagnosis in pediatric idiopathic intracranial hypertension (IIH).
designRetrospective, international, multisite study.
participantsPediatric patients (2-18 years of age at diagnosis) with IIH.
main outcome measuresBody mass index (BMI), height, and weight Z-scores; sexual maturation.
methodsCases of IIH were identified retrospectively based on diagnostic code, pediatric neuro-ophthalmologist databases, or both and updated diagnostic criteria (2013) were applied to confirm definite IIH. Anthropometric measurements were converted into age- and gender-specific height, weight, and BMI Z-scores CDC 2000 growth charts. When available, sexual maturation was noted.
resultsTwo hundred thirty-three cases of definite IIH were identified across 8 sites. In boys, a moderate association between age and BMI Z-scores was noted (Pearson's correlation coefficient, 0.50; 95% confidence interval [CI], 0.30-0.66; P < 0.001; n = 72), and in girls, a weak association was noted (Pearson's correlation coefficient, 0.34; 95% CI, 0.20-0.47; P < 0.001; n = 161). The average patient was more likely to be overweight at diagnosis at age 6.7 years in girls and 8.7 years in boys, and obese at diagnosis at age 12.5 years in girls and 12.4 years in boys. Compared with age- and gender-matched reference values, early adolescent patients were taller for age (P = 0.002 in girls and P = 0.02 in boys). Data on Tanner staging, menarchal status, or both were available in 25% of cases (n = 57/233). Prepubertal participants (n = 12) had lower average BMI Z-scores (0.95±1.98) compared with pubertal participants (n = 45; 1.92±0.60), but this result did not reach statistical significance (P = 0.09).
conclusionsWith updated diagnostic criteria and pediatric-specific assessments, the present study identifies 3 subgroups of pediatric IIH: a young group that is not overweight, an early adolescent group that is either overweight or obese, and a late adolescent group that is mostly obese. Data also suggest that the early adolescent group with IIH may be taller than age- and gender-matched reference values. Understanding these features of pediatric IIH may help to illuminate the complex pathogenesis of this condition.
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