Evidence map›Paper›PMID 27692455›Full record

ReviewDermatologic clinics2016

In Vivo and Ex Vivo Confocal Microscopy for Dermatologic and Mohs Surgeons.

Caterina Longo, Moira Ragazzi, Milind Rajadhyaksha, Kishwer Nehal, Antoni Bennassar, Giovanni Pellacani, Josep Malvehy Guilera

Open access · greenAbstract readReview
In one paragraph

Review in Dermatologic clinics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Accuracy of Ex-vivo Fluorescence Confocal Microscopy in Margin Assessment of Solid Tumors: A Systematic Review.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023
    Pooled it
  3. Article
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  8. In vivo and ex vivo sonographic evaluation of tumor margins during micrographic-controlled surgery: a promising new tool in dermato-oncology?Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Article
  9. Review
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  12. Article
  13. Review
  14. TerahertzAPL bioengineering · 2024
    Article
  15. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Caterina LongoSkin Cancer Unit, Arcispedale Santa Maria Nuova-IRCCS, viale Risorgimento 80, Reggio Emilia 42100, Italy. Electronic address: longo.caterina@gmail.com.
Moira RagazziPathology Unit, Arcispedale Santa Maria Nuova-IRCCS, viale Risorgimento 80, Reggio Emilia 42100, Italy.
Milind RajadhyakshaDermatology Service, Memorial Sloan Kettering Cancer Center, 160 East 53rd Street, New York, NY 10022, USA.
Kishwer NehalDermatology Service, Memorial Sloan Kettering Cancer Center, 160 East 53rd Street, New York, NY 10022, USA.
Antoni BennassarMelanoma Unit, Dermatology Department, Hospital Clinic and Institut d'Investigacions Biomediques August Pi I Sunyer, Barcelona, Spain.
Giovanni PellacaniDermatology Unit, UniMore, Modena, Italy.
Josep Malvehy GuileraMelanoma Unit, Dermatology Department, Hospital Clinic and Institut d'Investigacions Biomediques August Pi I Sunyer, Barcelona, Spain.
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESMemorial Sloan Kettering Cancer Center · USOspedale Santa Maria · IT

Funding

Intra-operative confocal imaging to guide Mohs surgeryR01EB012466 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI RAJADHYAKSHA, MILIND · 2010 to 2012
$2.3M
Intra-operative confocal imaging-guided Mohs surgeryR01EB002715 · NIBIB · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI RAJADHYAKSHA, MILIND · 2003 to 2006
$1.7M
NIBIB NIH HHS R01 EB002715NIBIB NIH HHS R01 EB012466
6 · The paper itself

Abstract

Confocal microscopy is a modern imaging device that has been extensively applied in skin oncology. More specifically, for tumor margin assessment, it has been used in two modalities: reflectance mode (in vivo on skin patient) and fluorescence mode (on freshly excised specimen). Although in vivo reflectance confocal microscopy is an add-on tool for lentigo maligna mapping, fluorescence confocal microscopy is far superior for basal cell carcinoma and squamous cell carcinoma margin assessment in the Mohs setting. This article provides a comprehensive overview of the use of confocal microscopy for skin cancer margin evaluation.

Indexed as

Basal Cell CarcinomaCarcinoma, Squamous CellHumansHutchinson's Melanotic FreckleIntravital MicroscopyMicroscopy, ConfocalMicroscopy, FluorescenceMohs SurgerySkinSkin NeoplasmsConfocal microscopyEx vivoIn vivoMohs surgery

Identifiers

PMID27692455
PMCPMC5570550
OpenAlexW2523844578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.