Evidence map›Paper›PMID 27692344›Full record

ArticleMolecular oncology2016

Autophagy inhibition upregulates CD4

Paul Zarogoulidis, Savvas Petanidis, Kalliopi Domvri, Efrosini Kioseoglou, Doxakis Anestakis, Lutz Freitag, Konstantinos Zarogoulidis, Wolfgang Hohenforst-Schmidt, Wilfried Eberhardt

Open access · bronzeAbstract read
In one paragraph

Article in Molecular oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. The role of miRNAs in Behçet's disease.Frontiers in immunology · 2023
    Review
  10. Review
  11. Autophagy and tumorigenesis.The FEBS journal · 2022
    Review
  12. Article
  13. Cancer Stem Cells: An Ever-Hiding Foe.Experientia supplementum (2012) · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Role of autophagy on cancer immune escape.Cell communication and signaling : CCS · 2021
    Review
  18. Article
  19. Review
  20. Therapeutic Targeting of MicroRNAs in the Tumor Microenvironment.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Paul ZarogoulidisPulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, 57010, Greece.
Savvas PetanidisDepartment of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece. Electronic address: spetanid@auth.gr.
Kalliopi DomvriPulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, 57010, Greece.
Efrosini KioseoglouDepartment of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece.
Doxakis AnestakisDepartment of Medicine, Laboratory of General Biology, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece; Department of Medicine, Laboratory of Forensic Medicine and Toxicology, Aristotle University of Thessaloniki, 54124, Greece.
Lutz FreitagDepartment of Interventional Pneumology, Ruhrlandklinik, University Hospital Essen, University of Essen-Duisburg, Tueschener Weg 40, 45239, Essen, Germany.
Konstantinos ZarogoulidisPulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, 57010, Greece.
Wolfgang Hohenforst-SchmidtMedical Clinic I, "Fuerth" Hospital, University of Erlangen, 91054, Fuerth, Germany.
Wilfried EberhardtDivision of Thoracic Oncology, Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, 45122, Essen, Germany.
Aristotle University of Thessaloniki · GRRuhrlandklinik · DEUniversitätsklinikum Erlangen · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemoresistance is a major challenge in lung cancer treatment. Recent findings have revealed that autophagic mechanism contributes significantly to immunosuppressive related chemoresistance. For that reason, targeting autophagy-related immunosuppression is an important approach to reverse tumor drug resistance. In this study, we report for the first time that autophagy inhibition triggers upregulation of CD4

Indexed as

AdultAgedAged, 80 and overAntineoplastic AgentsAntirheumatic AgentsApoptosisAutophagyCarboplatinCarcinoma, Non-Small-Cell LungCD4-Positive T-LymphocytesChloroquineDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansLungLung NeoplasmsABCC2 protein, humanAntineoplastic AgentsAntirheumatic AgentsCarboplatinChloroquineMicroRNAsMIRN155 microRNA, humanMultidrug Resistance-Associated Protein 2TNF-Related Apoptosis-Inducing LigandChemoresistanceLung cancermiR-155TRAILTumor infiltrating lymphocytes

Identifiers

PMID27692344
PMCPMC5423126
OpenAlexW2518662777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.