ArticleJournal of substance abuse treatment2016
Mortality Rates Among Substance Use Disorder Participants in Clinical Trials: Pooled Analysis of Twenty-Two Clinical Trials Within the National Drug Abuse Treatment Clinical Trials Network.
Article in Journal of substance abuse treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Mortality among adolescent and young adults in specialized substance use treatment: a Swedish register study.Child and adolescent psychiatry and mental health · 2026Article
- Characteristics linked to mortality risk among individuals with drug use disorders enrolled in drug rehabilitation facilities in Japan.PCN reports : psychiatry and clinical neurosciences · 2025Article
- The cost-effectiveness of long-term post-treatment peer recovery support services in the United States.The American journal of drug and alcohol abuse · 2025Article
- Community-involved economic evaluation and development of a cost-effectiveness calculator for two peer-driven substance use interventions.Frontiers in public health · 2025Article
- Project CHARIOT: study protocol for a hybrid type 1 effectiveness-implementation study of comprehensive tele-harm reduction for engagement of people who inject drugs in HIV prevention services.Addiction science & clinical practice · 2024Article
- Forecasting drug-overdose mortality by age in the United States at the national and county levels.PNAS nexus · 2024Article
- Effect of selective and family-based prevention on addiction susceptibility, affiliation with deviant peers, risk-taking, and risk and protective factors of substance use in high-risk adolescents: A randomized clinical trial.Journal of education and health promotion · 2024Article
- "We want everything in a one-stop shop": acceptability and feasibility of PrEP and buprenorphine implementation with mobile syringe services for Black people who inject drugs.Harm reduction journal · 2022Article
- Using a Syndemics Framework to Understand How Substance Use Contributes to Morbidity and Mortality among People Living with HIV in Africa: A Call to Action.International journal of environmental research and public health · 2022Article
- Diagnostic Accuracy of the Drug Use Disorder Identification Test and Its Short Form, the DUDIT-C, in German Adolescent Psychiatric Patients.Frontiers in psychology · 2021Article
- Traumatic Events and Substance Use Disorders in Adolescents.Frontiers in psychiatry · 2020Article
- Supporting Providers After Drug Overdose Death.The American journal of psychiatry · 2019Article
- Sex and gender differences in substance use disorders.Clinical psychology review · 2018Review
- Data sharing platforms for de-identified data from human clinical trials.Clinical trials (London, England) · 2018Article
- Drug abuse-associated mortality across the lifespan: a population-based longitudinal cohort and co-relative analysis.Social psychiatry and psychiatric epidemiology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMost substance use disorders (SUD) treatment clinical trials are too short and small to reliably estimate the incidence of rare events like death.
objectiveThe aim of this study is to estimate the overall mortality rates among a SUD treatment-seeking population by pooling participants from multiple clinical trials conducted through the National Institute on Drug Abuse (NIDA)-sponsored National Drug Abuse Treatment Clinical Trials Network (CTN).
participantsDrug and or alcohol users (N=9866) who sought treatment and participated in one of the twenty-two CTN trials. MEASUREMENTS: Data were collected through randomized clinical trials in national community treatment programs for SUD. Pooled analysis was performed to assess age- and gender-standardized mortality rate(s) (SM rate(s)), and mortality ratio(s) (SM ratio(s)) of CTN trial participants compared to the U.S. general population.
resultsThe age- and gender-SM rate among CTN trials participants was 1403 (95% CI: 862-2074) per 100,000 person years (PY) compared to 542 (95% CI: 541-543) per 100,000 PY among the U.S. general population in 2005. By gender, age-adjusted SM ratio for female CTN trial participants was over five times (SM ratio=5.35, 95% CI: 3.31-8.19)), and for male CTN trial participants, it was over three times (SM ratio=3.39, 95% CI: 2.25-4.90) higher than their gender comparable peers in the U.S. general population.
conclusionsAge and gender-standardized mortality rates and ratios among NIDA CTN SUD treatment-seeking clinical trial participants are higher than the age and gender comparable U.S. general population. The overall mortality rates of CTN trial participants are similar to in-treatment mortality reported in large U.S. and non-U.S. cohorts of opioid users. Future analysis with additional CTN trial participants and risk times will improve the stability of estimates, especially within subgroups based on primary substance of abuse. These SUD mortality rates can be used to facilitate safety monitoring within SUD clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.