Evidence map›Paper›PMID 27692171›Full record

ArticleMedical hypotheses2016

Exosomes are possibly used as a tool of immune regulation during the dendritic cell-based immune therapy against HIV-I.

Joel Henrique Ellwanger, Sergio Crovella, Edione Cristina Dos Reis, Alessandra Pontillo, José Artur Bogo Chies

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Article in Medical hypotheses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Joel Henrique EllwangerLaboratório de Imunogenética, Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil.
Sergio CrovellaLaboratório de Imunopatologia Keizo Azami, Departamento de Genética, Universidade Federal de Pernambuco (UFPE), Brazil.
Edione Cristina Dos ReisLaboratório de Imunogenética, Departamento de Imunologia, Instituto de Ciências Biológicas, Universidade de São Paulo (USP), Brazil.
Alessandra PontilloLaboratório de Imunogenética, Departamento de Imunologia, Instituto de Ciências Biológicas, Universidade de São Paulo (USP), Brazil.
José Artur Bogo ChiesLaboratório de Imunogenética, Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul (UFRGS), Brazil. Electronic address: jabchies@terra.com.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cell (DC)-based immune therapy (IT) against HIV showed variable results. It is known that different factors influence host response to DC-IT. Exosomes derived from DC are regulators of the immune system. In this context, here we hypothesize about the role of the DC-derived exosomes on the DC-IT response. Based on data from RT-PCR array genes expression (focused on the TSG101 gene, an exosome marker) and flow cytometry experiments of a DC-IT against HIV-1 clinical trial, we hypothesize that: During the DC-IT exosomes are used as an additional tool for immune system modulation. In addition, we believe that a low release of exosomes can be more beneficial for the DC-IT response than a high release of exosomes. Our data reinforce the concept that exosomes can act as an immune regulatory tool, however not in a generalized manner, but in a highly precise way. Our hypothesis is based in preliminary experimental data, thus, it should be tested using experimental and functional strategies involving a great number of patients. Once the hypothesis confirmed, the immunomodulatory role of the exosomes during DC-IT must be considered as an important factor in the (I) evaluation, (II) modulation, and (III) success of DC-IT against HIV.

Indexed as

AdultClinical Trials as TopicDendritic CellsDNA-Binding ProteinsDown-RegulationEndosomal Sorting Complexes Required for TransportExosomesFlow CytometryHIV-1HIV InfectionsHumansImmune SystemImmunologic FactorsImmunotherapyMaleMonocytesDNA-Binding ProteinsEndosomal Sorting Complexes Required for TransportImmunologic FactorsTranscription FactorsTsg101 Protein

Identifiers

PMID27692171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.