ArticleThe Journal of general virology2016
Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family.
Article in The Journal of general virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed.
- Identification of novel hepaciviruses in rock pigeon (Columba livia [Gmelin, 1789]), rusty-margined flycatcher (Myiozetetes cayanensis [Linnaeus, 1766]), and Hispaniolan amazon (Amazona ventralis [Statius Muller, 1776]).Archives of virology · 2026Article
- Co-Circulation of Divergent Strains Supports Vector-Mediated Transmission of Rodent Hepacivirus J (Viruses · 2026Article
- A pegivirus associated with encephalitis in red-legged partridges shows neurotropism across avian species.Nature communications · 2026Article
- Molecular prevalence, genomic characterization, and zoonotic potential of novel paramyxovirus and hepacivirus in Alexandromys fortis, Republic of Korea.Veterinary research · 2026Article
- The origins and potential cross-species transmission of paramyxoviruses and other RNA viruses between native snakes and invasive Burmese pythons in the Florida Everglades.Journal of virology · 2026Article
- Identification and Long-Term Detection ofViruses · 2026Article
- Maternal health status is associated with paired maternal and cord blood virome and mother-to-infant transmission.NPJ biofilms and microbiomes · 2025Article
- Identification of a novel pegivirus in reindeer (Rangifer tarandus valentinae) in Northeastern China.BMC veterinary research · 2025Article
- Hepatitis C virus NS3 helicase contributes to (-) strand RNA synthesis.Nature communications · 2025Article
- First detection of equine hepacivirus RNA in Stomoxys calcitrans (Diptera, Muscidae) in eastern Austria.BMC veterinary research · 2025Article
- Integrated analysis of protein sequence and structure redefines viral diversity and the taxonomy of thebioRxiv : the preprint server for biology · 2025Article
- A novel genotype ofFrontiers in cellular and infection microbiology · 2025Article
- Detection and characterization of bovine hepacivirus in cattle and sheep from Hulunbuir, northeastern China.Frontiers in cellular and infection microbiology · 2025Article
- Identification of novel hepaciviruses andVirus evolution · 2025Article
- Design and optimization of a multiplex real-time PCR assay for detection of Hepatitis C virus (HCV), Human immunodeficiency virus-1 (HIV-1) and Human hepegivirus-1 (HHpgV-1).Gastroenterology and hepatology from bed to bench · 2025Article
- Detection of a novel hepacivirus in wild cavies (Cavia aperea aperea).Archives of virology · 2024Article
- Effect of direct-acting antivirals on the titers of human pegivirus 1 during treatment of chronic hepatitis C patients.Microbiology spectrum · 2024Article
- Field-applicable simultaneous multiplex LAMP assay for screening HBV and HCV co-infection in a single tube.BMC infectious diseases · 2024Article
- The Blood Virome: A new frontier in biomedical science.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Review
- Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
Proposals are described for the assignment of recently reported viruses, infecting rodents, bats and other mammalian species, to new species within the Hepacivirus and Pegivirus genera (family Flaviviridae). Assignments into 14 Hepacivirus species (Hepacivirus A-N) and 11 Pegivirus species (Pegivirus A-K) are based on phylogenetic relationships and sequence distances between conserved regions extracted from complete coding sequences for members of each proposed taxon. We propose that the species Hepatitis C virus is renamed Hepacivirus C in order to acknowledge its unique historical position and so as to minimize confusion. Despite the newly documented genetic diversity of hepaciviruses and pegiviruses, members of these genera remain phylogenetically distinct, and differ in hepatotropism and the possession of a basic core protein; pegiviruses in general lack these features. However, other characteristics that were originally used to support their division into separate genera are no longer definitive; there is overlap between the two genera in the type of internal ribosomal entry site and the presence of miR-122 sites in the 5' UTR, the predicted number of N-linked glycosylation sites in the envelope E1 and E2 proteins, the presence of poly U tracts in the 3' UTR and the propensity of viruses to establish a persistent infection. While all classified hepaciviruses and pegiviruses have mammalian hosts, the recent description of a hepaci-/pegi-like virus from a shark and the likely existence of further homologues in other non-mammalian species indicate that further species or genera remain to be defined in the future.
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