Evidence map›Paper›PMID 27690265›Full record

SynthesisAging2016

DNA methylation-based measures of biological age: meta-analysis predicting time to death.

Brian H Chen, Riccardo E Marioni, Elena Colicino, Marjolein J Peters, Cavin K Ward-Caviness, Pei-Chien Tsai, Nicholas S Roetker, Allan C Just, Ellen W Demerath, Weihua Guan and 56 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03353597 (Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects), which is not on this map. Cited by 671 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
671citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03353597 phase1 / phase2unknown statusnot on this mapstarted 2018, after this paper: background citation

Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects

TypeinterventionalSponsorChandra DuggiralaRan2018 to 2022Enrolled2,120ConditionsAgingArmsPlasma Transfusion
3 · Its place in the literature

Who cites it

671 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Epigenetic clocks of biological aging and cognitively healthy longevity: the Women's Health Initiative Memory Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Extracellular vesicles and epigenetic aging clocks in tissue aging: an exosome-focused conceptual framework with a focus on skin.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Review
  20. Article

611 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

66 authors.

Brian H ChenLongitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Riccardo E MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Elena ColicinoLaboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Marjolein J PetersDepartment of Internal Medicine, Erasmus University Medical Centre, Rotterdam, 3000 CA, The Netherlands.
Cavin K Ward-CavinessInstitute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Pei-Chien TsaiDepartment of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
Nicholas S RoetkerDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA.
Allan C JustLaboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Ellen W DemerathDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA.
Weihua GuanDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, 55455, ; USA.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX, ; USA.
Myriam FornageHuman Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX, ; USA.
Stephanie StudenskiLongitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Amy R VandiverCenter for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, ; USA.
Ann Zenobia MooreLongitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Toshiko TanakaLongitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Douglas P KielDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, ; USA.
Liming LiangDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Pantel VokonasDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Joel SchwartzDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Kathryn L LunettaThe NHLBI's Framingham Heart Study, Framingham, MA 01702, USA.
Joanne M MurabitoThe NHLBI's Framingham Heart Study, Framingham, MA 01702, USA.
Stefania BandinelliGeriatric Unit, Usl Centro Toscana Florence, Italy.
Dena G HernandezLaboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA.
David MelzerEpidemiology and Public Health, Medical School, University of Exeter, RILD, Exeter EX2 5DW, ; UK.
Michael NallsLaboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA.
Luke C PillingEpidemiology and Public Health, Medical School, University of Exeter, RILD, Exeter EX2 5DW, ; UK.
Timothy R PriceLaboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA.
Andrew B SingletonLaboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA.
Christian GiegerInstitute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Rolf HolleInstitute of Health Economics and Health Care Management, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Anja KretschmerInstitute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Florian KronenbergDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck 6020, Austria.
Sonja KunzeInstitute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Jakob LinseisenInstitute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Christine MeisingerInstitute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Wolfgang RathmannInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany.
Melanie WaldenbergerInstitute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Peter M VisscherCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Sonia ShahQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
Naomi R WrayQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
Allan F McRaeQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Centre, Rotterdam, 3015 CN, The Netherlands.
Albert HofmanDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Centre, Rotterdam, 3000 CA, The Netherlands.
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
Themistocles AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, ; Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Morgan E LevineVA Palo Alto Health Care System, Palo Alto CA 94304, USA.
Ake T LuVA Palo Alto Health Care System, Palo Alto CA 94304, USA.
Philip S TsaoDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, ; Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Lifang HouRobert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern UniversityChicago, IL 60611, USA.
JoAnn E MansonCenter for Translational Science Children's National Medical Center, George Washington University, Washington, DC 20010, USA.
Cara L CartyDepartment of Family Medicine and Public Health, University of California-San Diego, La Jolla, CA 92093-0725, ; USA.
Andrea Z LaCroixDepartment of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA.
Alexander P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, ; USA.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
Andrew P FeinbergCenter for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, ; USA.
Daniel LevyThe NHLBI's Framingham Heart Study, Framingham, MA 01702, USA.
Andrea BaccarelliLaboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Joyce van MeursDepartment of Internal Medicine, Erasmus University Medical Centre, Rotterdam, 3000 CA, The Netherlands.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
James S PankowDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Steve HorvathVA Palo Alto Health Care System, Palo Alto CA 94304, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maria Jose Rosa · 2014 to 2026
$21.3M
Characterization of Normal Genomic VariabilityZIAAG000932 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW · 2009 to 2024
$11.3M
Exploring the Role of the Brain Epigenome: Cognitive Decline and Life ExperiencesRF1AG036042 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2016 to 2016
$5.5M
Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging CohortR01ES015172 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI SCHWARTZ, JOEL D · 2006 to 2015
$4.8M
The Role and Genetic Mechanism of Epigenetic Plasticity in Age-Related DiseaseR01AG042187 · NIA · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE, FEINBERG, ANDREW P. · 2011 to 2015
$4.1M
Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging CohortR01ES025225 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BACCARELLI, ANDREA · 2016 to 2020
$2.9M
Molecular and Epigenetic Mitochondriomics of Air Particles, Lead and CognitionR01ES021733 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2012 to 2015
$2.4M
Exceptional Aging Across the Life Span: Framingham StudyR01AG029451 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MURABITO, JOANNE M · 2008 to 2011
$1.3M
Systems genetic and reverse phenotypic analysis of age and retirementR01AG042511 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE · 2013 to 2016
$1.3M
The epiGenetIcs Leads to aGe-relAted diseases (GILGA-mesh) NetworkU34AG051425 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE · 2015 to 2017
$954k
ARRA NIH HHSBiotechnology and Biological Sciences Research CouncilChief Scientist OfficeMedical Research Council MR/K026992/1Medical Research Council MR/M013111/1NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS RC2 HL102419NIA NIH HHS HHSN271201100004CNIA NIH HHS R01 AG029451NIA NIH HHS R01 AG042187NIA NIH HHS R01 AG042511NIA NIH HHS RF1 AG036042NIA NIH HHS U34 AG051425NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES023450NIEHS NIH HHS R01 ES015172NIEHS NIH HHS R01 ES021733NIEHS NIH HHS R01 ES025225NIGMS NIH HHS T32 GM007309Wellcome TrustWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Estimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of chronological age, epigenetic age assessed in blood predicted all-cause mortality in four human cohorts. Here, we expanded our original observation to 13 different cohorts for a total sample size of 13,089 individuals, including three racial/ethnic groups. In addition, we examined whether incorporating information on blood cell composition into the epigenetic age metrics improves their predictive power for mortality. All considered measures of epigenetic age acceleration were predictive of mortality (p≤8.2x10

Indexed as

AgingDNA MethylationEpigenesis, GeneticFemaleHumansLogistic ModelsMaleMortalityRacial GroupsRisk FactorsSurvival AnalysisT-Lymphocyte Subsetsall-cause mortalityDNA methylationepigenetic clockepigeneticslifespanmortality

Identifiers

PMID27690265
PMCPMC5076441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.