ArticleJournal of vision2016
Luminance and chromatic signals interact differently with melanopsin activation to control the pupil light response.
Article in Journal of vision, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
- Trial
- Simulated and natural changes in intraocular transparency selectively affect photoreceptor-specific pupil responses.Scientific reports · 2026Article
- Binocular combination in the autonomic nervous system.PloS one · 2026Article
- Melanopsin-mediated image statistics from natural and human-made environments.Scientific reports · 2025Article
- The Impact of Pupil Constriction on the Relationship Between Melanopic EDI and Melatonin Suppression in Young Adult Males.Journal of biological rhythms · 2024Article
- Different rules for binocular combination of luminance flicker in cortical and subcortical pathways.eLife · 2023Article
- Colour opponency is widespread across the mouse subcortical visual system and differentially targets GABAergic and non-GABAergic neurons.Scientific reports · 2023Article
- A five-primary Maxwellian-view display for independent control of melanopsin, rhodopsin, and three-cone opsins on a fine spatial scale.Journal of vision · 2022Article
- Melanopsin photoreception differentially modulates rod-mediated and cone-mediated human temporal vision.iScience · 2022Article
- Deep learning-based pupil model predicts time and spectral dependent light responses.Scientific reports · 2021Article
- "Blue Sky Effect": Contextual Influences on Pupil Size During Naturalistic Visual Search.Frontiers in psychology · 2021Article
- Crosstalk: The diversity of melanopsin ganglion cell types has begun to challenge the canonical divide between image-forming and non-image-forming vision.The Journal of comparative neurology · 2020Review
- Selective amplification of ipRGC signals accounts for interictal photophobia in migraine.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Prediction accuracy of L- and M-cone based human pupil light models.Scientific reports · 2020Article
- Melanopsin contributions to non-visual and visual function.Current opinion in behavioral sciences · 2019Article
- Appearance of Maxwell's spot in images rendered using a cyan primary.Vision research · 2019Article
- The flicker Pupil Light Response (fPLR).Translational vision science & technology · 2019Article
- Photoreceptor inputs to pupil control.Journal of vision · 2019Article
- A quantitative analysis of the contribution of melanopsin to brightness perception.Scientific reports · 2019Article
- The role of vasopressin in olfactory and visual processing.Cell and tissue research · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin. These cells receive afferent inputs from rods and cones, which provide inputs to the postreceptoral visual pathways. It is unknown, however, how melanopsin activation is integrated with postreceptoral signals to control the pupillary light reflex. This study reports human flicker pupillary responses measured using stimuli generated with a five-primary photostimulator that selectively modulated melanopsin, rod, S-, M-, and L-cone excitations in isolation, or in combination to produce postreceptoral signals. We first analyzed the light adaptation behavior of melanopsin activation and rod and cones signals. Second, we determined how melanopsin is integrated with postreceptoral signals by testing with cone luminance, chromatic blue-yellow, and chromatic red-green stimuli that were processed by magnocellular (MC), koniocellular (KC), and parvocellular (PC) pathways, respectively. A combined rod and melanopsin response was also measured. The relative phase of the postreceptoral signals was varied with respect to the melanopsin phase. The results showed that light adaptation behavior for all conditions was weaker than typical Weber adaptation. Melanopsin activation combined linearly with luminance, S-cone, and rod inputs, suggesting the locus of integration with MC and KC signals was retinal. The melanopsin contribution to phasic pupil responses was lower than luminance contributions, but much higher than S-cone contributions. Chromatic red-green modulation interacted with melanopsin activation nonlinearly as described by a "winner-takes-all" process, suggesting the integration with PC signals might be mediated by a postretinal site.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.