ArticleMolecules (Basel, Switzerland)2016
Group I Intron Internal Guide Sequence Binding Strength as a Component of Ribozyme Network Formation.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Prebiotic RNA Network Formation: A Taxonomy of Molecular Cooperation.Life (Basel, Switzerland) · 2017Article
- Topological and thermodynamic factors that influence the evolution of small networks of catalytic RNA species.RNA (New York, N.Y.) · 2017Article
- Special Issue: Ribozymes and RNA Catalysis.Molecules (Basel, Switzerland) · 2017Article
- Article
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3 authors.
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Abstract
Origins-of-life research requires searching for a plausible transition from simple chemicals to larger macromolecules that can both hold information and catalyze their own production. We have previously shown that some group I intron ribozymes possess the ability to help synthesize other ribozyme genotypes by recombination reactions in small networks in an autocatalytic fashion. By simplifying these recombination reactions, using fluorescent anisotropy, we quantified the thermodynamic binding strength between two nucleotides of two group I intron RNA fragments for all 16 possible genotype combinations. We provide evidence that the binding strength (
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