Evidence map›Paper›PMID 27689882›Full record

ArticleBioconjugate chemistry2016

Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery.

Giulio F Paciotti, Jielu Zhao, Shugeng Cao, Peggy J Brodie, Lawrence Tamarkin, Marja Huhta, Lonnie D Myer, Jay Friedman, David G I Kingston

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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  19. ImmunoPET Imaging of Pancreatic Tumors withMolecular imaging and biology · 2021
    Article
  20. Nanogold Functionalized With Lipoamide-Frontiers in chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giulio F PaciottiCytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Jielu ZhaoDepartment of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
Shugeng CaoDepartment of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
Peggy J BrodieDepartment of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.
Lawrence TamarkinCytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Marja HuhtaCytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Lonnie D MyerCytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Jay FriedmanCytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
David G I KingstonDepartment of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech , Blacksburg, Virginia 24061, United States.

Funding

Development of Tumor-Targeted Pegylated Colloidal Gold *R43CA119399 · NCI · CYTIMMUNE SCIENCES, INC. · PI PACIOTTI, GIULIO FRANCO · 2006 to 2007
$500k
NCI NIH HHS R43 CA119399
6 · The paper itself

Abstract

The synthesis of a series of thiolated paclitaxel analogs is described as part of a novel nanomedicine program aimed at developing formulations of paclitaxel that will bind to gold nanoparticles for tumor targeted drug delivery. Preliminary evaluation of the new nanomedicine composed of 27 nm gold nanoparticles, tumor necrosis factor alpha (TNFα), thiolated polyethylene glycol (PEG-thiol), and one of several thiolated paclitaxel analogs is presented.

Indexed as

AnimalsBuffersCell Line, TumorChemistry Techniques, SyntheticDrug CarriersDrug LiberationGoldHumansMetal NanoparticlesMiceModels, MolecularPaclitaxelPolyethylene GlycolsProtein ConformationTumor Necrosis Factor-alphaBuffersDrug CarriersGoldPaclitaxelPolyethylene GlycolsTumor Necrosis Factor-alpha

Identifiers

PMID27689882
PMCPMC5356508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.