Evidence map›Paper›PMID 27689830›Full record

ArticleJournal of magnetic resonance imaging : JMRI2017

RGD targeting of human ferritin iron oxide nanoparticles enhances in vivo MRI of vascular inflammation and angiogenesis in experimental carotid disease and abdominal aortic aneurysm.

Toshiro Kitagawa, Hisanori Kosuge, Masaki Uchida, Yasunori Iida, Ronald L Dalman, Trevor Douglas, Michael V McConnell

Open access · hybridAbstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 53 citations in OpenAlex.

  1. Iron Dysregulation and Vascular Diseases: A Contemporary Review.Journal of the American Heart Association · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Iron Overload and Abdominal Aortic Aneurysm.Reviews in cardiovascular medicine · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. The mechanism and therapy of aortic aneurysms.Signal transduction and targeted therapy · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Bioengineered Ferritin Nanocarriers for Cancer Therapy.International journal of molecular sciences · 2021
    Review
  17. Review
  18. Review
  19. The potential application of gold-apoferritin nanocages conjugated with 2-amino-2-deoxy-glucose for imaging of breast cancer cells.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
  20. Tumor Targeting by αACS nano · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Toshiro KitagawaCardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.
Hisanori KosugeCardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.
Masaki UchidaDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA.
Yasunori IidaCardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.
Ronald L DalmanCardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.
Trevor DouglasDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA.
Michael V McConnellCardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.
Stanford University · USIndiana University Bloomington · USResonance Research (United States) · US

Funding

Signature Protein Profiles to Identify AAAsP50HL083800 · NHLBI · STANFORD UNIVERSITY · PI CONNOLLY, ANDREW J · 2006 to 2010
$13.7M
Phage-based targeted imaging probes and their application to vascular diseasesR01EB012027 · NIBIB · TRUSTEES OF INDIANA UNIVERSITY · PI DOUGLAS, TREVOR · 2011 to 2014
$2.6M
Multi-modality Cellular Imaging of Vascular InflammationR01HL078678 · NHLBI · STANFORD UNIVERSITY · PI MCCONNELL, MICHAEL V · 2004 to 2007
$1.6M
NHLBI NIH HHS P50 HL083800NHLBI NIH HHS R01 HL078678NIBIB NIH HHS R01 EB012027
6 · The paper itself

Abstract

purposeTo evaluate Arg-Gly-Asp (RGD)-conjugated human ferritin (HFn) iron oxide nanoparticles for in vivo magnetic resonance imaging (MRI) of vascular inflammation and angiogenesis in experimental carotid disease and abdominal aortic aneurysm (AAA). MATERIALS AND

methodsHFn was genetically engineered to express the RGD peptide and Fe

resultsRGD-HFn-Fe

conclusionRGD-HFn-Fe LEVEL OF EVIDENCE: 1 J. Magn. Reson. Imaging 2017;45:1144-1153.

Indexed as

AnimalsAortic Aneurysm, AbdominalCarotid ArteriesCarotid Artery DiseasesDisease Models, AnimalFerric CompoundsFerritinsInflammationMagnetic Resonance ImagingMaleMiceNanoparticlesNeovascularization, PathologicOligopeptidesVascular Diseasesarginyl-glycyl-aspartic acidFerric Compoundsferric oxideFerritinsOligopeptidesaneurysmsangiogenesisatherosclerosisironnanoparticlesRGD

Identifiers

PMID27689830
PMCPMC5352511
OpenAlexW2529609982

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.