ArticleNeuroRehabilitation2016
Pain, cognition and quality of life associate with structural measures of brain volume loss in multiple sclerosis.
Article in NeuroRehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The neural correlates of well-being: A systematic review of the human neuroimaging and neuropsychological literature.Cognitive, affective & behavioral neuroscience · 2019Pooled it
- Neuroimaging Correlates of Patient-Reported Outcomes in Multiple Sclerosis.Degenerative neurological and neuromuscular disease · 2023Article
- Fatigue in patients with hereditary neuropathy with liability to pressure palsies.Annals of clinical and translational neurology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMultiple sclerosis (MS) is characterized by physical and mental impairments that often result in pain and reduced quality of life.
objectiveTo understand the relationship of pain, quality of life, and cognition to structural measures of brain volume.
methodsBehavioral measures were assessed in a single session using standardized questionnaires and rating scales. Brain volume measures were assessed with structural magnetic resonance imaging (MRI).
resultsTwenty-nine individuals with relapsing-remitting MS and 29 age-matched controls participated in this study. Pain, quality of life, and cognition were significantly interrelated. Higher fluid attenuation inversion recovery weighted lesion volume was significantly associated with increased reports of pain (p = 0.01), lower physical quality of life (p < 0.0001), and lower cognitive performance (p = 0.001) in our cohort.
conclusionsAssessment of pain and quality of life along with structural MRI highlights the importance of understanding structure-function relationships in MS and suggests that therapists should not only evaluate individuals for cognition and quality of life, but should consider rehabilitation goals that target these areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.