Evidence map›Paper›PMID 27689529›Full record

ArticleAging2016

Global gene profiling of aging lungs in Atp8b1 mutant mice.

Ramani Soundararajan, Timothy M Stearns, Alexander Czachor, Jutaro Fukumoto, Christina Turn, Emma Westermann-Clark, Mason Breitzig, Lee Tan, Richard F Lockey, Benjamin L King and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ramani SoundararajanDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Timothy M StearnsMDI Biological Laboratory, Salisbury Cove, ME 04672, USA.
Alexander CzachorDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Jutaro FukumotoDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Christina TurnUniversity of Florida College of Medicine, Gainesville, FL 32608, USA.
Emma Westermann-ClarkDivision of Allergy and Immunology, Department of Internal Medicine, James A Haley Veterans Hospital, Tampa, FL 33612, USA.
Mason BreitzigDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Lee TanDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Richard F LockeyDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Benjamin L KingMDI Biological Laboratory, Salisbury Cove, ME 04672, USA.
Narasaiah KolliputiDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
University of South Florida · USMount Desert Island Biological Laboratory · USFlorida College · USJames A. Haley Veterans' Hospital · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
Molecular Mechanisms of Hyperoxic Lung InjuryR01HL105932 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KOLLIPUTI, NARASAIAH · 2011 to 2019
$2.9M
NHLBI NIH HHS R01 HL105932NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318
6 · The paper itself

Abstract

objectiveRecent studies implicate cardiolipin oxidation in several age-related diseases.

methodsWe performed Affymetrix gene profiling of lungs isolated from young (7-9 wks, n=6) and aged (14 months, 14 M, n=6) C57BL/6 and

resultsGlobal transcriptome analysis revealed 532 differentially expressed genes in

conclusionBased on transcriptome profiling, our study indicates that

Indexed as

ADAMTS ProteinsAdenosine TriphosphatasesAgingAnimalsGene Expression ProfilingLungMatrix Metalloproteinase 13MiceMice, TransgenicOligonucleotide Array Sequence AnalysisPhospholipid Transfer ProteinsTranscriptomeAdamts2 protein, mouseADAMTS ProteinsAdenosine TriphosphatasesAtp8b1 protein, mouseMatrix Metalloproteinase 13Phospholipid Transfer ProteinsagingAtp8b1 mutantgene profilinglungstranscriptome

Identifiers

PMID27689529
PMCPMC5076460
OpenAlexW2527564169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.