Evidence map›Paper›PMID 27689396›Full record

ArticleOncotarget2016

Prognostic nomogram for previously untreated adult patients with acute myeloid leukemia.

Zhuojun Zheng, Xiaodong Li, Yuandong Zhu, Weiying Gu, Xiaobao Xie, Jingting Jiang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Nomogram incorporating clinicopathological parameters to predict the survival of patients with mantle cell lymphoma.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhuojun ZhengDepartment of Hematology, The Third Affiliated Hospital of Soochow University, China.
Xiaodong LiDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, China.
Yuandong ZhuDepartment of Hematology, The Third Affiliated Hospital of Soochow University, China.
Weiying GuDepartment of Hematology, The Third Affiliated Hospital of Soochow University, China.
Xiaobao XieDepartment of Hematology, The Third Affiliated Hospital of Soochow University, China.
Jingting JiangDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to perform an acceptable prognostic nomogram for acute myeloid leukemia. The clinical data from 311 patients from our institution and 165 patients generated with Cancer Genome Atlas Research Network were reviewed. A prognostic nomogram was designed according to the Cox's proportional hazard model to predict overall survival (OS). To compare the capacity of the nomogram with that of the current prognostic system, the concordance index (C-index) was used to validate the accuracy as well as the calibration curve. The nomogram included 6 valuable variables: age, risk stratifications based on cytogenetic abnormalities, status of FLT3-ITD mutation, status of NPM1 mutation, expression of CD34, and expression of HLA-DR. The C-indexes were 0.71 and 0.68 in the primary and validation cohort respectively, which were superior to the predictive capacity of the current prognostic systems in both cohorts. The nomogram allowed both patients with acute myeloid leukemia and physicians to make prediction of OS individually prior to treatment.

Indexed as

NomogramsAdolescentAdultAgedAged, 80 and overFemalefms-Like Tyrosine Kinase 3HLA-DR AntigensHumansLeukemia, Myeloid, AcuteMaleMiddle AgedMutationNuclear ProteinsNucleophosminPrognosisFLT3 protein, humanfms-Like Tyrosine Kinase 3HLA-DR AntigensNPM1 protein, humanNuclear ProteinsNucleophosminacute myeloid leukemianomogrampredictionprognosisTCGA

Identifiers

PMID27689396
PMCPMC5342098
OpenAlexW2526276446

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.