Evidence map›Paper›PMID 27689339›Full record

ReviewClinical and experimental immunology2017

Circulating immune cells in multiple sclerosis.

A P Jones, A G Kermode, R M Lucas, W M Carroll, D Nolan, P H Hart

Abstract readReview
In one paragraph

Review in Clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Current neuropharmacology · 2025
    Article
  4. Current Knowledge about CD3International journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Analysis of cerebrospinal fluid cells by flow cytometry: Comparison to conventional cytology.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2023
    Article
  9. Article
  10. Article
  11. The Role of Exposomes in the Pathophysiology of Autoimmune Diseases II: Pathogens.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A P JonesTelethon Kids Institute, The University of Western Australia, Perth, WA.
A G KermodeCentre for Neuromuscular and Neurological Disorders, Western Australian Neuroscience Research Institute, The University of Western Australia, Sir Charles Gairdner Hospital, Perth, WA.
R M LucasNational Centre for Epidemiology and Population Health, Research School of Population Health, Australian National University, Canberra, ACT.
W M CarrollCentre for Neuromuscular and Neurological Disorders, Western Australian Neuroscience Research Institute, The University of Western Australia, Sir Charles Gairdner Hospital, Perth, WA.
D NolanInstitute for Immunology and Infectious Disease, Murdoch University, Perth, WA.
P H HartTelethon Kids Institute, The University of Western Australia, Perth, WA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating T and B lymphocytes contribute to the pathogenesis of the neuroinflammatory autoimmune disease, multiple sclerosis (MS). Further progress in the development of MS treatments is dependent upon a greater understanding of the immunological disturbances that underlie the disease. Analyses of circulating immune cells by flow cytometry have revealed MS-associated alterations in the composition and function of T and B cell subsets, including temporal changes associated with disease activity. Disturbances in circulating immune populations reflect those observed in the central nervous system and include skewing towards proinflammatory CD4

Indexed as

AnimalsBlood CellsB-LymphocytesHumansImmunophenotypingLymphocyte SubsetsMultiple SclerosisT-LymphocytesB cellsflow cytometrymultiple sclerosisT cells

Identifiers

PMID27689339
PMCPMC5217886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.