Evidence map›Paper›PMID 27689141›Full record

ArticleJournal of bone reports & recommendations

Adjuvant Aromatase Inhibitors in Early Breast Cancer May Not Increase the Risk of Falls.

Palak Choksi, Margaret E Williams, Kelley M Kidwel, Julia Stella, Mary Soyster, David Hanauer, Catherine Van Poznak

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone reports & recommendations. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Joint pain and falls among women with breast cancer on aromatase inhibitors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Article
  3. Risk Factors for Falls in Adult Cancer Survivors: An Integrative Review.Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Palak ChoksiDepartment of Internal Medicine, University of Michigan Health Systems, USA.
Margaret E WilliamsDepartment of Internal Medicine, University of Michigan Health Systems, USA.
Kelley M KidwelDepartment of Biostatistics, School of Public Health, University of Michigan, USA.
Julia StellaUniversity of Michigan Medical School, USA.
Mary SoysterUniversity of Connecticut School of Medicine, USA.
David HanauerDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, USA.
Catherine Van PoznakDepartment of Internal Medicine, University of Michigan Health Systems, USA.
Michigan Medicine · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients with Metastatic CancerK23DE020197 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VAN POZNAK, CATHERINE H · 2009 to 2013
$670k
NCI NIH HHS P30 CA046592NIDCR NIH HHS K23 DE020197
6 · The paper itself

Abstract

backgroundFalling increases the risk for fracture. The impact of adjuvant aromatase inhibitors (AI) on the risk of falls is undefined.

methodsA retrospective case control study was performed examining women with early stage breast cancer on adjuvant AI and matched controls without cancer. Fall and fracture data were abstracted from the medical record.

resultsMatched pairs of 332 women were identified (total N = 664). There was no statistically significant difference in the odds of a fall between cases and controls, p = 0.86. Similarly, the odds of a fracture between cases and controls was not significantly different, p = 1.0. There were 35 pairs in which the case fractured but the control did not and equal number of pairs where the control fractured but the case did not. For pairs in which control fractured but case did not, the median age at fracture was significant higher than that for pairs in which case fractured but the control did not (71

conclusionThis study did not identify a difference in the incidence of falls or fractures in women on adjuvant AI compared to their age matched controls without breast cancer. Prospective studies of falls and fracture in women on adjuvant AI therapy compared to age match controls would aid in the identification of fracture risk.

Indexed as

Aromatase inhibitorsEarly stage breast cancerFallsFracturesPostmenopausal women

Identifiers

PMID27689141
PMCPMC5036389
OpenAlexW2517850423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.