ArticleJournal of renal injury prevention2016
Effect of aerobic exercise against vanadyl sulphate-induced nephrotoxicity and hepatotoxicity in rats.
Article in Journal of renal injury prevention, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Boswellic Acid and Carnosine Ameliorate Vanadyl-Sulfate-Induced Renal Damage via Regulating Nrf2/HO-1 and PI3K/AKT Pathways.Biological trace element research · 2026Article
- Galaxaura elongata Extract (GE) Modulates Vanadyl Sulfate-Induced Renal Damage via Regulating TGF-β/Smads and Nrf2/NF-κB Pathways.Biological trace element research · 2022Article
- The Protective Role of Silymarin and Aerobic Exercise on Gentamicin-induced Nephrotoxicity.International journal of preventive medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVanadium compounds are insulin like drugs which are accompanied with nephrotoxicity and hepatotoxicity as their major side effects. Aerobic exercise is well known as an approach to reduce the side effects of many drugs.
objectivesThis study was designed to determine the role of aerobic exercise against vanadyl sulphate induced nephrotoxicity and hepatotoxicity in male rats. MATERIALS AND
methodsTwenty-four male Wistar rats were randomly divided into three groups. Group I had aerobic exercise on a treadmill 5 days/week for 6 weeks. Group II received vanadyl sulphate (50 mg/kg/week; i.p.) for 6 weeks. Group III had combination of exercise and vanadyl sulphate therapy as groups 1 and 2. At the end of study, blood samples were obtained, and the animals were sacrificed for the tissues injury determination.
resultsVanadyl sulphate alone increased serum levels of blood urea nitrogen (BUN), creatinine (Cr), and kidney weight (KW) and kidney tissue damage score (KTDS) (P<0.05). These observations revealed nephrotoxicity induced by vanadyl sulphate, although exercise training did not attenuate these results. In addition, vanadyl sulphate alone induced liver tissue damage score and exercise training intensified it insignificantly, while the serum levels of aspartate amino transferase and alanine amino transferase were greater in exercise alone group than others groups.
conclusionAerobic exercise could not attenuate vanadyl sulphate induced nephrotoxicity and hepatotoxicity. These findings must be considered when vanadyl sulphate is suggested as insulin like drug.
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Registered trials
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