Evidence map›Paper›PMID 27689094›Full record

ArticleBioMed research international

Preparation of Thermosensitive Gel for Controlled Release of Levofloxacin and Their Application in the Treatment of Multidrug-Resistant Bacteria.

Danilo Antonini Alves, Daisy Machado, Adriana Melo, Rafaella Fabiana Carneiro Pereira, Patrícia Severino, Luciana Maria de Hollanda, Daniele Ribeiro Araújo, Marcelo Lancellotti

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03472144 (Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03472144 phase3unknown statusnot on this map

Gel-Sinuplasty for Chronic Rhinosinusitis With and Without Nasal Polyposis

TypeinterventionalSponsorLifeBridge HealthRan2017 to 2019Enrolled60ConditionsChronic Sinusitis, Ethmoidal, Chronic Sinusitis - Ethmoidal Anterior, Chronic Sinusitis, Chronic Sinusitis - Ethmoidal, PosteriorArmsgel loaded with steroids (momentasone), gel loaded with antibiotic (Levofloxacin), gel loaded with both steroids and antibiotic
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 27 citations in OpenAlex.

  1. Sprayable ciprofloxacin-loaded poloxamer hydrogels for wound infection treatment.Journal of drug delivery science and technology · 2023
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Danilo Antonini AlvesLaboratory of Biotechnology (LABIOTEC), Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Daisy MachadoLaboratory of Biotechnology (LABIOTEC), Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Adriana MeloLaboratory of Biotechnology (LABIOTEC), Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.ORCID 0000-0002-3925-0707
Rafaella Fabiana Carneiro PereiraLaboratory of Biotechnology (LABIOTEC), Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Patrícia SeverinoLaboratory of Nanotechnology and Nanomedicine (LNMed), Institute of Technology and Research (ITP), Aracaju, SE, Brazil; Tiradentes University (UNIT), Aracaju, SE, Brazil.ORCID 0000-0001-6527-6612
Luciana Maria de HollandaTiradentes University (UNIT), Aracaju, SE, Brazil.
Daniele Ribeiro AraújoCenter of Natural Sciences and Humanities, Federal University of ABC (UFABC), Santo André, SP, Brazil.
Marcelo LancellottiLaboratory of Biotechnology (LABIOTEC), Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil; Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.ORCID 0000-0002-4257-1034
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Tiradentes · BRUniversidade Federal do ABC · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Levofloxacin is a synthetic broad-spectrum antibacterial agent for oral or intravenous administration. Chemically, levofloxacin is the levorotatory isomer (L-isomer) of racemate ofloxacin, a fluoroquinolone antibacterial agent. Quinolone derivatives rapidly and specifically inhibit the synthesis of bacterial DNA. Levofloxacin has

Identifiers

PMID27689094
PMCPMC5027370
OpenAlexW2508091476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.