ArticleBioMed research international
Aberrant LncRNA Expression Profile in a Contusion Spinal Cord Injury Mouse Model.
Article in BioMed research international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- MST2 Acts via AKT Activity to Promote Neurite Outgrowth and Functional Recovery after Spinal Cord Injury in Mice.Molecular neurobiology · 2024Article
- Microarray analysis of lncRNAs and mRNAs in spinal cord contusion rats with iPSC-derived A2B5Heliyon · 2024Article
- Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells.Frontiers in molecular neuroscience · 2024Article
- Tanshinone IIA protects motor neuron-like NSC-34 cells against lipopolysaccharide-induced cell injury by the regulation of the lncRNA TCTN2/miR-125a-5p/DUSP1 axis.Regenerative therapy · 2023Article
- Circulating exosomal lncRNA contributes to the pathogenesis of spinal cord injury in rats.Neural regeneration research · 2023Article
- Expression profiles of long non-coding RNAs in neurogenic bladder of spinal cord injured rats: a transcriptomic analysis.Translational andrology and urology · 2022Article
- Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury.Neural regeneration research · 2022Article
- Coding and long non-coding gene expression changes in the CNS traumatic injuries.Cellular and molecular life sciences : CMLS · 2022Review
- Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury.Neural regeneration research · 2022Article
- Microarray and Bioinformatics Analysis of Differential Gene and lncRNA Expression during Erythropoietin Treatment of Acute Spinal Cord Injury in Rats.Computational and mathematical methods in medicine · 2022Review
- LncRNA H19 Regulates Lipopolysaccharide (LPS)-Induced Apoptosis and Inflammation of BV2 Microglia Cells Through Targeting miR-325-3p/NEUROD4 Axis.Journal of molecular neuroscience : MN · 2021Article
- The role of lncRNA-MEG/miR-21-5p/PDCD4 axis in spinal cord injury.American journal of translational research · 2021Article
- Roles of Non-coding RNAs in Central Nervous System Axon Regeneration.Frontiers in neuroscience · 2021Review
- Inhibition of lncRNA H19/miR-370-3p pathway mitigates neuronal apoptosis in anTranslational neuroscience · 2021Article
- Expression of long non-coding RNAs in complete transection spinal cord injury: a transcriptomic analysis.Neural regeneration research · 2020Article
- Long non-coding RNAs in the spinal cord injury: Novel spotlight.Journal of cellular and molecular medicine · 2019Review
- Functional roles of lncRNAs and its potential mechanisms in neuropathic pain.Clinical epigenetics · 2019Review
- The Emerging Role of lncRNAs in Spinal Cord Injury.BioMed research international · 2019Review
- Role of Long Noncoding RNAs and Circular RNAs in Nerve Regeneration.Frontiers in molecular neuroscience · 2019Review
- Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1/Bioscience reports · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long noncoding RNAs (LncRNAs) play a crucial role in cell growth, development, and various diseases related to the central nervous system. However, LncRNA differential expression profiles in spinal cord injury are yet to be reported. In this study, we profiled the expression pattern of LncRNAs using a microarray method in a contusion spinal cord injury (SCI) mouse model. Compared with a spinal cord without injury, few changes in LncRNA expression levels were noted 1 day after injury. The differential changes in LncRNA expression peaked 1 week after SCI and subsequently declined until 3 weeks after injury. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate the reliability of the microarray, demonstrating that the results were reliable. Gene ontology (GO) analysis indicated that differentially expressed mRNAs were involved in transport, cell adhesion, ion transport, and metabolic processes, among others. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that the neuroactive ligand-receptor interaction, the PI3K-Akt signaling pathway, and focal adhesions were potentially implicated in SCI pathology. We constructed a dynamic LncRNA-mRNA network containing 264 LncRNAs and 949 mRNAs to elucidate the interactions between the LncRNAs and mRNAs. Overall, the results from this study indicate for the first time that LncRNAs are differentially expressed in a contusion SCI mouse model.
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Registered trials
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