Evidence map›Paper›PMID 27689064›Full record

ReviewProstate international2016

Oxidative stress in prostate cancer patients: A systematic review of case control studies.

Byeongsang Oh, Gemma Figtree, Daniel Costa, Thomas Eade, George Hruby, Stephanie Lim, Aymen Elfiky, Neil Martine, David Rosenthal, Stephen Clarke and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Prostate international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Byeongsang OhNorthern Sydney Cancer Centre, Royal North Shore Hospital, Sydney Medical School, Sydney, NSW, Australia; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Gemma FigtreeOxidative Signaling Group, Department of Cardiology, Kolling Institute, University of Sydney, Royal North Shore Hospital, NSW, Australia.
Daniel CostaPain Management Research Institute, University of Sydney, Royal North Shore Hospital, NSW, Australia.
Thomas EadeNorthern Sydney Cancer Centre, Royal North Shore Hospital, Sydney Medical School, Sydney, NSW, Australia.
George HrubyNorthern Sydney Cancer Centre, Royal North Shore Hospital, Sydney Medical School, Sydney, NSW, Australia.
Stephanie LimDepartment of Medical Oncology, Liverpool Hospital, Ingham Institute for Applied Medical Research, NSW, Australia.
Aymen ElfikyDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Neil MartineDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
David RosenthalDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Stephen ClarkeNorthern Sydney Cancer Centre, Royal North Shore Hospital, Sydney Medical School, Sydney, NSW, Australia.
Michael BackNorthern Sydney Cancer Centre, Royal North Shore Hospital, Sydney Medical School, Sydney, NSW, Australia.
Royal North Shore Hospital · AUDana-Farber Cancer Institute · USUniversity of Sydney · AUHarvard University · USLiverpool Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer (PCa) is the most common cancer in men in Western countries. In-vitro and in-vivo studies suggest that oxidative stress (OS) and antioxidants play a key role in the pathogenesis of chronic diseases including PCa, which is promoted by the production of reactive oxygen species and impaired antioxidant defense mechanisms. This study evaluates the association between OS and men with PCa.

methodsA literature search was carried out on Medline, PubMed, and ScienceDirect databases, as well as manual searches from inception up to August 2015 using the keywords "Oxidative stress" or "Reactive oxygen species" or "Lipid peroxidation" AND "Prostate cancer." All studies including data on the measurement of OS biomarkers in PCa were included.

resultsTwenty-three case control studies were retrieved with sample sizes ranging from 15 to 3,613 (6,439 participants in total). Markers of OS were significantly higher in patients with PCa compared with control groups in 21 studies. Two self-controlled case studies comparing OS between PCa cells and non-PCa cells in tissue biopsies found OS to be statistically higher in PCa cancer cells. Results on markers of antioxidant capacity (superoxide dismutase, catalase, glutathione, glutathione reductase, glutathione peroxidase, uric acid, lutein, lycopene, beta carotein, vitamin A, vitamin C, vitamin E, and total antioxidants) were not completely consistent in their association with PCa.

conclusionsUpregulated OS profiles and impairment of antioxidant defense systems may play a role in men with PCa. To confirm these findings, robust clinical trials utilizing a personalized approach which monitors both OS and antioxidant markers during therapy are warranted.

Indexed as

AntioxidantOxidative stressPeroxidationProstate cancerReactive oxygen species

Identifiers

PMID27689064
PMCPMC5031904
OpenAlexW2404861246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.