ArticleNeuroImage. Clinical
Volumetric, relaxometric and diffusometric correlates of psychotic experiences in a non-clinical sample of young adults.
Article in NeuroImage. Clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The Effect of Developmental Trauma on Brain Structures Involved in Threat and Memory Processing and Its Relation to Psychotic Experiences in Adulthood.Schizophrenia bulletin · 2026Article
- Increased Brain-Age Gap in Young Adults With Psychotic Experiences.Biological psychiatry global open science · 2026Article
- Molecular and micro-architectural mapping of gray matter alterations in psychosis.Molecular psychiatry · 2025Article
- Exploring associations between psychotic experiences and structural brain age: a population-based study in late adolescence.medRxiv : the preprint server for health sciences · 2024Article
- Magnetic resonance advanced imaging analysis in adolescents: cortical thickness study to identify attenuated psychosis syndrome.Neuroradiology · 2023Article
- The impact of cumulative obstetric complications and childhood trauma on brain volume in young people with psychotic experiences.Molecular psychiatry · 2023Article
- Longitudinal Gray Matter Development Associated With Psychotic Experiences in Young People.Biological psychiatry global open science · 2023Article
- The impact of genetic risk for Alzheimer's disease on the structural brain networks of young adults.Frontiers in neuroscience · 2022Article
- Environmental Risk Factors and Psychotic-like Experiences in Children Aged 9-10.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Grey and white matter associations of psychotic-like experiences in a general population sample (UK Biobank).Translational psychiatry · 2021Article
- Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study.Brain imaging and behavior · 2020Article
- Population neuroimaging: generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort.Wellcome open research · 2020Article
- MRI Indices of Cortical Development in Young People With Psychotic Experiences: Influence of Genetic Risk and Persistence of Symptoms.Schizophrenia bulletin · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundGrey matter (GM) abnormalities are robust features of schizophrenia and of people at ultra high-risk for psychosis. However the extent to which neuroanatomical alterations are evident in non-clinical subjects with isolated psychotic experiences is less clear.
methodsIndividuals (mean age 20 years) with (n = 123) or without (n = 125) psychotic experiences (PEs) were identified from a population-based cohort. All underwent T1-weighted structural, diffusion and quantitative T1 relaxometry MRI, to characterise GM macrostructure, microstructure and myelination respectively. Differences in quantitative GM structure were assessed using voxel-based morphometry (VBM). Binary and ordinal models of PEs were tested. Correlations between socioeconomic and other risk factors for psychosis with cortical GM measures were also computed.
resultsGM volume in the left supra-marginal gyrus was reduced in individuals with PEs relative to those with no PEs. The greater the severity of PEs, the greater the reduction in T1 relaxation rate (R1) across left temporoparietal and right pre-frontal cortices. In these regions, R1 was positively correlated with maternal education and inversely correlated with general psychopathology.
conclusionsPEs in non-clinical subjects were associated with regional reductions in grey-matter volume reduction and T1 relaxation rate. The alterations in T1 relaxation rate were also linked to the level of general psychopathology. Follow up of these subjects should clarify whether these alterations predict the later development of an ultra high-risk state or a psychotic disorder.
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