ArticleBrain and behavior2016
Kappa-opioid receptors differentially regulate low and high levels of ethanol intake in female mice.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Kappa-opioid receptor stimulation in the nucleus accumbens shell and ethanol drinking: Differential effects by rostro-caudal location and level of drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- A critical review of effects on ethanol intake of the dynorphin/kappa opioid receptor system in the extended amygdala: From inhibition to stimulation.Alcohol, clinical & experimental research · 2023Review
- Blockade of kappa-opioid receptors amplifies microglia-mediated inflammatory responses.Pharmacology, biochemistry, and behavior · 2022Article
- Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake.Molecular psychiatry · 2021Article
- Kappa opioid receptors in the bed nucleus of the stria terminalis regulate binge-like alcohol consumption in male and female mice.Neuropharmacology · 2020Article
- Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol.Alcoholism, clinical and experimental research · 2017Review
- Homer2 and Alcohol: A Mutual Interaction.Frontiers in psychiatry · 2017Review
- Kappa-opioid receptors differentially regulate low and high levels of ethanol intake in female mice.Brain and behavior · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
introductionStudies in laboratory animals and humans indicate that endogenous opioids play an important role in regulating the rewarding value of various drugs, including ethanol (EtOH). Indeed, opioid antagonists are currently a front-line treatment for alcoholism in humans. Although roles for mu- and delta-opioid receptors have been characterized, the contribution of kappa-opioid receptors (KORs) is less clear. There is evidence that changes in KOR system function can decrease or increase EtOH drinking, depending on test conditions. For example, female mice lacking preprodynorphin - the precursor to the endogenous KOR ligand dynorphin - have reduced EtOH intake. Considering that KORs can regulate dopamine (DA) transmission, we hypothesized that KORs expressed on DA neurons would play a prominent role in EtOH intake in females.
methodsWe used a Cre/
resultsKOR deletion decreased preference for EtOH, although this effect was less pronounced when EtOH intake increased beyond relatively low levels. DISCUSSION: Our findings indicate that KOR activation increases EtOH drinking via effects mediated, at least in part, by KORs on DA neurons. While the mechanisms of this regulation remain unknown, previous work suggests that alterations in negative reinforcement processes or sensitivity to the sensory properties of EtOH can affect preference and intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.