ArticleCartilage2016
Bilayer Implants: Electromechanical Assessment of Regenerated Articular Cartilage in a Sheep Model.
Article in Cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Conducting Polymer Coatings for Bioelectronic Arthroscopy Probes.Advanced healthcare materials · 2025Article
- Chitosan/Platelet-Rich Plasma Implants in an Ovine Arthroscopic Model of Meniscus Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Osteochondral Repair and Electromechanical Evaluation of Custom 3D Scaffold Microstructured by Direct Laser Writing Lithography.Cartilage · 2021Article
- Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches-A Review.Polymers · 2021Review
- Article
- Quantitative Arthroscopic Assessment of Articular Cartilage Quality by Means of Cartilage Electromechanical Properties.Arthroscopy techniques · 2018Article
- [Effect of polycaprolactone-ascobic acid scaffold in repairing articular cartilage defects in rabbits].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the regenerative capacity of 2 distinct bilayer implants for the restoration of osteochondral defects in a preliminary sheep model.
methodsCritical sized osteochondral defects were treated with a novel biomimetic poly-ε-caprolactone (PCL) implant (Treatment No. 2; n = 6) or a combination of Chondro-Gide and Orthoss (Treatment No. 1; n = 6). At 19 months postoperation, repair tissue (n = 5 each) was analyzed for histology and biochemistry. Electromechanical mappings (Arthro-BST) were performed ex vivo.
resultsHistological scores, electromechanical quantitative parameter values, dsDNA and sGAG contents measured at the repair sites were statistically lower than those obtained from the contralateral surfaces. Electromechanical mappings and higher dsDNA and sGAG/weight levels indicated better regeneration for Treatment No. 1. However, these differences were not significant. For both treatments, Arthro-BST revealed early signs of degeneration of the cartilage surrounding the repair site. The International Cartilage Repair Society II histological scores of the repair tissue were significantly higher for Treatment No. 1 (10.3 ± 0.38 SE) compared to Treatment No. 2 (8.7 ± 0.45 SE). The parameters cell morphology and vascularization scored highest whereas tidemark formation scored the lowest.
conclusionThere was cell infiltration and regeneration of bone and cartilage. However, repair was incomplete and fibrocartilaginous. There were no significant differences in the quality of regeneration between the treatments except in some histological scoring categories. The results from Arthro-BST measurements were comparable to traditional invasive/destructive methods of measuring quality of cartilage repair.
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