ReviewInternational journal of endocrinology2016
Inositols in the Treatment of Insulin-Mediated Diseases.
Review in International journal of endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03283813 (Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of a Supplementation With Zinc and Myo-inositol in Paediatric Obesity
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Inositol and Non-Alcoholic Fatty Liver Disease: A Systematic Review on Deficiencies and Supplementation.Nutrients · 2020Pooled it
- Metabolic health during a randomized controlled lifestyle intervention in women with PCOS.European journal of endocrinology · 2021Trial
- Observational
- Review
- "Forever young at the table": metabolic effects of eating speed in obesity.Journal of translational medicine · 2021Observational
- PCOS and nutritional approaches: Differences between lean and obese phenotype.Metabolism open · 2021Article
- Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats.Nutrients · 2021Article
- Melatonin and Myo-Inositol: Supporting Reproduction from the Oocyte to Birth.International journal of molecular sciences · 2021Review
- Placental Inositol Reduced in Gestational Diabetes as Glucose Alters Inositol Transporters and IMPA1 Enzyme Expression.The Journal of clinical endocrinology and metabolism · 2021Article
- D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes.Frontiers in endocrinology · 2021Article
- Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study.Journal of diabetes research · 2021Article
- Meta-analysis of gene expression profiles of lean and obese PCOS to identify differentially regulated pathways and risk of comorbidities.Computational and structural biotechnology journal · 2020Article
- An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques-A Literature Review.Advances in therapy · 2018Review
- Metformin improves ovarian follicle dynamics by reducing theca cell proliferation and CYP-17 expression in an androgenized rat model.Journal of ovarian research · 2018Article
- Soy, Soy Foods and Their Role in Vegetarian Diets.Nutrients · 2018Review
- Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials.Endocrine connections · 2017Article
- Erratum to "Inositols in the Treatment of Insulin-Mediated Diseases".International journal of endocrinology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Both isomers have been shown to exert insulin-mimetic action and to lower postprandial glucose. Further, insulin resistance-related diseases were associated to derangements in inositol metabolism. Thus, the aim of this review is to provide current evidence on the potential benefits of inositol isomers (MYO-INS and DCI) in the treatment of disease associated to insulin resistance such as polycystic ovary syndrome (PCOS), gestational diabetes, and metabolic syndrome. Finally, molecular insights into inositol insulin-sensitizing effects will be covered focusing on the possible role of inositol glycans as insulin second messengers.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.