Evidence map›Paper›PMID 27688729›Full record

ArticleContemporary oncology (Poznan, Poland)2016

Histological characterisation and prognostic evaluation of 62 gastric neuroendocrine carcinomas.

Yujie Deng, Xiaohui Chen, Yuhong Ye, Xi Shi, Kunshou Zhu, Liming Huang, Sheng Zhang, Mingang Ying, Xuede Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary oncology (Poznan, Poland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yujie DengDepartment of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China; These two authors contributed equally to this paper.
Xiaohui ChenDivision of Oncological Surgery, Fujian Provincial Cancer Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China; These two authors contributed equally to this paper.
Yuhong YeDepartment of Pathology, The First Affiliated Hospital of Fujian Medical University, PR China.
Xi ShiDepartment of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.
Kunshou ZhuDivision of Oncological Surgery, Fujian Provincial Cancer Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.
Liming HuangDepartment of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.
Sheng ZhangDepartment of Pathology, The First Affiliated Hospital of Fujian Medical University, PR China.
Mingang YingDivision of Oncological Surgery, Fujian Provincial Cancer Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.
Xuede LinDepartment of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, PR China.
First Affiliated Hospital of Fujian Medical University · CNFujian Provincial Cancer Hospital · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyTo determine the significance of expression of synaptophysin, chromogranin A, and Ki-67 and their association with clinicopathological parameters, and to find out the possible prognostic factors in gastric neuroendocrine carcinoma (G-NEC). MATERIAL AND

methodsWe investigated the immunohistochemical features and prognosis of 62 G-NECs, and evaluated the association among expressions of synaptophysin, chromogranin A, and Ki-67, clinicopathological variables, and outcome.

resultsChromogranin A expression was found more commonly in small-cell NECs (9/9, 100%) than in large-cell NECs (27/53, 51%) (p = 0.008). No statistical significance was found in Ki-67 (p = 0.494) or synaptophysin (p > 0.1) expression between NEC cell types. Correlation analyses revealed that Ki-67 expression was significantly associated with mid-third disease of stomach (p = 0.005) and vascular involvement (p = 0.006), and had a trend of significant correlation with tumour relapse (p = 0.078). High expression of chromogranin A was significantly associated with histology of small-cell NECs (p = 0.008) and lesser tumour greatest dimension (p = 0.038). The prognostic significance was determined by means of Kaplan-Meier survival estimates and log-rank tests, and as a result, early TNM staging and postoperative chemotherapy were found to be correlated with longer overall survival (p < 0.05). Univariate analysis revealed associations between poor prognosis in NECs and several factors, including high TNM staging (p = 0.048), vascular involvement (p = 0.023), relapse (p = 0.004), and microscopic/macroscopic residual tumour (R1/2, p < 0.001). In a multivariate analysis, relapse was identified as the sole independent prognostic factor.

conclusionsNo significant correlation between survival and expression of synaptophysin, chromogranin A, or Ki-67 has been determined in G-NECs. Our study indicated that early diagnosis, no-residual-tumour resection, and postoperative chemotherapy were possible prognostic factors.

Indexed as

chromogranin AKi-67neuroendocrine carcinomaprognosisstomach

Identifiers

PMID27688729
PMCPMC5032160
OpenAlexW2553032614

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.