Evidence map›Paper›PMID 27688687›Full record

ArticleThe Journal of international medical research2016

Incidence and characteristics of hepatitis E virus infection in children in Assiut, Upper Egypt.

Gamal Hasan, Asaad Assiri, Naglaa Marzuuk, Enas Daef, Sayed Abdelwahab, Ahmed Ahmed, Ismail Mohamad, Ayman Al-Eyadhy, Ali Alhaboob, Mohamad-Hani Temsah

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Hepatitis E virus prevalence in Egyptian children with transfusion-dependent thalassemia.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Gamal Hasan1 Department of Paediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Asaad Assiri3 Prince Abdullah Bin Khaled Coeliac Disease Research Chair, Department of Paediatrics, King Khaled University Hospital and College of Medicine, King Saud University, Saudi Arabia.
Naglaa Marzuuk4 Department of Gastroenterology and Hepatology, Assiut Police Hospital, Assiut, Egypt.
Enas Daef5 Department of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Sayed Abdelwahab6 Department of Microbiology and Immunology, Faculty of Medicine, Minia University, Minia, Egypt.
Ahmed Ahmed7 Department of Paediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.
Ismail Mohamad1 Department of Paediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ayman Al-Eyadhy2 Department of Paediatrics, King Khaled University Hospital and College of Medicine, King Saud University, Saudi Arabia.
Ali Alhaboob2 Department of Paediatrics, King Khaled University Hospital and College of Medicine, King Saud University, Saudi Arabia.
Mohamad-Hani Temsah2 Department of Paediatrics, King Khaled University Hospital and College of Medicine, King Saud University, Saudi Arabia.
King Saud University · SAAssiut University · EGKing Khalid University Hospital · SAMinia University · EGSouth Valley University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective To describe the characteristics of hepatitis E virus (HEV) infection in a cohort of children from Upper Egypt using data from a large multicentre prospective study of acute viral hepatitis (AVH). Methods Data from subjects aged 2-18 years with AVH or close contacts of those with AVH found to have asymptomatic AVH were included in the analysis. Information concerning medical history, clinical examination, liver function tests and screening for hepatotropic viruses was recorded and analysed. Results A total of 123 patients (73 boys, 50 girls) were included in the analysis. Of these, 33 (26.8%) had HEV infection, 17 (13.8%) had hepatitis A virus infection, 10 (8.1%) had hepatitis B virus infection, 14 (11.4%) had cytomegalovirus hepatitis, five (4.1%) had autoimmune hepatitis, 11 (8.9%) had hepatitis due to mixed viral infections and 33 (26.8%) had non A-E hepatitis. Overall, 38 (30.9%) had infection with HEV. HEV infection was significantly higher among those using underground wells as a water source compared with tap water. Liver enzymes were significantly raised in patients with non-HEV infection compared with those with HEV infection. Conclusions HEV is a significant cause of AVH among children in Upper Egypt. Contamination of drinking water appears to be a major source of infection. Screening for HEV should be considered in all Egyptian children with AVH.

Indexed as

AdolescentChildChild, PreschoolCytomegalovirus InfectionsDrinking WaterEgyptFemaleHepatitis AHepatitis, AutoimmuneHepatitis BHepatitis EHepatitis E virusHumansLiverLiver Function TestsMaleDrinking Wateracute viral hepatitisChildrenhepatitis EUpper Egyptwaterborne outbreak

Identifiers

PMID27688687
PMCPMC5536550
OpenAlexW2526717510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.